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Penile urethral stricture disease not associated with hypospadias is rare, and there is a wide range of commonly used surgical repair techniques for this disease. We sought to compile a multi-institutional database of patients who had surgical correction of strictures in the penile urethra not limited to the meatus, and who had no history of hypospadias, for analysis using the Trauma and Urologic Reconstructive Network of Surgeons length, urethral segment and etiology classification system. Methods: A retrospective database from 13 institutions was compiled of patients who had undergone surgical correction of Trauma and Urologic Reconstructive Network of Surgeons length, urethral segment and etiology urethral stricture segments S2b/S2c and excluding E5, with a minimum follow-up time of 4 months. Failure was defined as cystoscopically confirmed recurrence of a stricture measuring less than 16-Fr. Results: We analyzed 222 patients with a median age of 57 years and a follow-up of 49 months. The overall surgical success rate was 80.2%. On multivariate analysis, the two variables identified that were predictive of surgical success were stricture length ≤2 cm as well as use of a buccal mucosa graft as compared to use of a fasciocutaneous flap, which had success rates of 83% and 52%, respectively (P = 0.0004). No statistically significant differences were found based on incisional approach or surgical technique, nor were outcomes different based on etiology or preoperative patient demographics. Conclusions: Surgical repair of penile urethral strictures of non-hypospadiac origin have a favorable overall success rate, at 80.2%. Regardless of incisional approach or surgical technique, all operations appear to have similar outcomes other than repairs using fasciocutaneous flap, which were statistically less successful than those using buccal mucosa graft.

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multicentric dataset. Categorical and continuous variables were reported as IQRs or frequencies, and compared with c2 e and Student t tests, respectively. Univariable and multivariable Cox regression analyses were performed to identify predictors of pCKD (stages !3b) in both groups. For all statistical analyses, a two-sided p < 0.05 was considered significant.RESULTS: I-MIPN patients were older (p[0.001), with significantly lower baseline eGFR (p<0.001), higher ASA score, RENAL score, cT stage, CKD stages, lower preoperative hemoglobin levels and increased rate of major comorbidities (all p<0.05; Table 1). Warm ischemia time, positive surgical margins rate, length of hospital stay and trifecta were comparable between groups (each p>0.05), while I-MIPN patients had significantly higher pT stages, eGFR at discharge decrease and Clavien!3 complication rates (each p<0.001; Tab.2). On multivariable Cox regression analysis, in the elective series, hypertension (HR 3.17; 95% CI 1.34-7.46; p[0.008), ASA score (HR 2.66; 95%

CONCLUSIONS: Moses TM holmium laser technology provides a cost benefit for HoLEP in high volume centers. The benefit is driven by the reduced operative time per case.