The effectiveness of the single capacitor biphasic waveform may be explained by the second phase "burping" of the deleterious residual charge of the first phase that, in turn, reduces the synchronization requirement and the amplitude requirements of the first phase.

Impedance is the ratio of voltage to current in an electrical circuit. Cardiovascular implantable electronic devices measure impedance to assess the structural integrity electrical performance of leads, typically using subthreshold pulses. We review determinants of impedance, how it is measured, variation in clinically measured pacing and high-voltage impedance and impedance trends as a diagnostic for lead failure and lead-device connection problems. We consider the differential diagnosis of abnormal impedance and the approach to the challenging problem of a single, abnormal impedance measurement. Present impedance provides a specific but insensitive diagnostic. For pacing circuits, we review the complementary roles of impedance and more sensitive oversensing diagnostics. Shock circuits lack a sensitive diagnostic. This deficiency is particularly important for insulation breaches, which may go undetected and present with short circuits during therapeutic shocks. We consider new methods for measuring impedance that may increase sensitivity for insulation breaches.

A minimal model of the defibrillation capability of a monophasic capacitive discharge pulse is derived from the Weiss-Lapicque strength duration model. The model suggests that present, empirically derived values of pulse durations and tilts are close to optimum for presently used values of capacitors and electrode resistances. The model suggests that neither the tilt nor fixed duration specification is universally superior to the other for dealing with electrode resistance changes. A tilt specification would appear to best handle resistance decreases while a fixed duration specification would best handle resistance increases. The model was used to study the effect of capacitance changes. It appears that the optimum tilt and pulse duration vary with the capacitance value. The model further suggests that decreasing the capacitance from presently used values may lower defibrillation thresholds.

MOUCHAWAR, G., ET AL.: ICD Waveform Optimization: A Randomized, Prospective, Pair-Sampled Mul ticenter Study. The theoretical tissue model-based estimates of phase 1 and phase 2 duration of biphasic waveforms are considerably shorter than the pulse widths currently used in ICDs with standard tilt. This study used a tissue resistance/capacitance (RC) model to identify optimal biphasic pulse widths. By paired step-down defibrillation threshold (DFT) testing, the efficacy of standard versus "tuned" biphasic waveforms was evaluated in 91 patients. Standard waveforms consisted of a phase 1 set to 65% tilt and phase 2 = phase 1. The tuned waveform was based on an RC model of membrane characteristics with a time constant of 3.5 ms. The optimal phase 1 truncation point is at the peak of membrane response. The optimal phase 2 duration ends with a membrane response near or just below 0. In paired analysis, no sig nificant differences were found in DFT or impedance between standard and tuned waveforms. In patients with DFTs > 400 V, the tuned waveform lowered the DFT by an average of 38 V (P < 0.05). Multivariate analyses showed a significant inverse relationship between DFT and impedance (P < 0.001). As impedance increased, the tuned waveform was associated with DFTs comparable to the standard wave form with shorter pulse duration and lower delivered energy. No single tilt value allowing an easy calcu lation of delivered energy was related to ICD waveform efficacy. The use of ICDs with tuned optimal pulse durations offer a greater flexibility of choice for patients with high DFTs. (PACE 2000; 23:[Pt. II]:1992-1995