We present a case of spontaneous recanalization of the internal carotid artery (ICA) that occurred in a 51-year-old male patient. The occlusion of the right ICA was asymptomatic and was detected incidentally during imaging of the opposite carotid artery. The patient underwent neuroradiologic analysis and a tapered, flame-like occlusion suggestive of the right ICA dissection was detected. One month later, a carotid Doppler ultrasound demonstrated patent right carotid artery with normal spectral flow. Five-month follow-up showed that the ICA remained patent.

symptoms and 5 rashes that have not developed systemic signs (therapy was suspended). Lamotrigine is a well established antiepileptic known to be responsible for hypersensitivity reactions manifested through skin reactions. These kinds of ADRs are potentially life threatening if not recognized on time.The objective was to analyze and identify risk factors in cases of severe skin rashes associated with lamotrigine therapy. Participants, Materials/Methods: Review of collected ADRs from Agency's database by the keyword lamotrigine and evaluation of these reports. Results: Review of three cases of severe skin rashes caused by lamotrigine. Case 1: 16-year-old patient within few weeks of combined therapy with lamotrigine 75 mg and valproate 450 mg daily experienced febrile reaction, exfoliative rash, had difficulties swallowing, sore throat and generalized maculopapular rash. At the same time, Beta Hemolytic Streptococcus (BHS) was isolated and he received benzatin-fenoxymetil penicillin, antihistamines and corticosteroids but progression of symptoms continued. Lamotrigine was discontinued, patient recovered. Case 2: 4-year-old infant started receiving 10 mg lamotrigine daily with valproate 45 mg and clonazepam 1 g as a standard therapy. Twenty days afterwards mononucleosis like symptoms, maculopapular rash, enlarged spleen and lymph nodes along with high fever (40°C) developed. Lamotrigin was discontinued and patient recovered within 3 days. Case 3: 14-year-old female patient received valproate 750 mg. Within 43 days of receiving concomitant lamotrigine 25 mg daily she experienced vulval redness and itching, diarrhea and rash indicating systemic hypersensitivity reaction. Reaction ceased upon discontinuation of lamotrigine. Conclusions: In the presented cases we identified the cause of the severe ADRs as a result of given risk factors: too high dose, pediatric patients, interaction with valproate, drug-induced rash not recognized due to BHS infection respectively. The severity of rash in the reviewed cases and development of more severe symptoms has usually been related to duration of exposure to lamotrigine and it is not possible to predict reliably which rashes will prove to be serious or life threatening. That is why lamotrigine should ordinarily be discontinued at first signs of rash, unless the rash is clearly not drug related. 17Epilepsy and partial agenesis of corpus callosum (case report) Dubravka epić Grahovac, Antonija Ružić BarÐić & Tanja Grahovac Department of neurology, Faculty of Medicine, University of Rijeka, etaliÐte 13, divizije 24, 51000 Rijeka, Croatia E-mail: poliklinika.interneuron@ri.t-com.hr Introduction/Objectives: Epilepsy may be caused by number of different ethyologies. Seizures of partial origin with or without secondary generalization mostly have an underlying structural lesion and it is very important to notice present focal neurological deficit. Congenital malformations of the brain linked to epileptic seizures are well described and manifested in variable clinical spectrum. The associ...