Sensors based on the localized surface plasmon resonance (LSPR) effect are known as sensitive methods for refractive index measurements or for detection of specific binding reactions in biosensing due to a variation in layer thickness. Fiber based arrangements are able to perform such measurements with very small analyte volumina. A generalization of this concept for a multiplexed measurement of different biomolecules in a single fiber could be an attractive approach. We discuss the possibility of selectively sensitizing the inner surfaces of a suspended core fiber with two different metallic nanoparticle types in monolayers for such multiplexed measurements.
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