Abstract-The emergence of antibiotic resistant bacteria has been increasing, these have been appearing in wild animals for different reasons. For this reason, it is essential to determine whether the total isolated of lisa (Mugil incilis) coliforms captured from the Cartagena de Indias bay (Colombia) show resistance to different antibiotics. Lisas were fished in the Cartagena bay and then taken to the microbiology laboratory of the Engineering Faculty of the University of Cartagena, after which the bacteria were isolated from the gills and intestines. The determination of total coliforms was carried out using the MPN method. Of the isolated microorganisms (E. coli and Enterobacter aerogenes) the highest proportion showed resistance to the antibiotics evaluated, it was also observed that the highest susceptibility occurred against chloramphenicol, ceftriaxone and amikacin. Given the results, the high degree of pollution of the bay's waters is confirmed, in addition to the fact that the microorganisms showed resistance to the evaluated antibiotics and in some cases the same microorganism was resistant to more than two antibiotics.