Objective: To assess the efficacy of the PSYCHOPATHY.COMP program in reducing psychopathic traits among male detained youth. Method:In this controlled trial, a treatment group (n = 58) and a control group (n = 61) answered the Youth Psychopathic Traits Inventory-Short (YPIS) and the Proposed Specifiers for Conduct Disorder (PSCD) at baseline, posttreatment, and six months' follow-up. Treatment participants attended the PSYCHOPATHY.COMP; controls only received Treatment As Usual. Treatment effects were tested with latent growth curve models (LGCM).Results: At baseline, no significant differences between groups were found. Results from LGCM showed that condition was a significant predictor of change over time observed in almost all outcome measures. Concerning the YPIS, treatment participants presented a significant decrease both in the total score and in the YPIS factors scores when compared with the controls (medium/large effect sizes; growth modeling analysis -GMA d ranging from .58 to 1.12).Considering the PSCD, treatment participants also showed a significant decrease both in the total score and in the PSCD factors scores (except for the grandiose-manipulative factor) when compared with controls (medium effect sizes; GMA d ranging from .53 to .72). Results also showed that treatment effects were maintained six months after the PSYCHOPATHY.COMP completion. Conclusions:Findings indicate that the PSYCHOPATHY.COMP is a promising treatment approach to reduce psychopathic traits among male detained youth, suggesting that interventions targeting these traits should be considered in their rehabilitation, as the absence of tailored interventions may increase the levels of psychopathic traits and its associated risks.

This study investigated the occurrence of tetracyclines (TCs), namely minocycline (MIN), TC, and its epimer epitetracycline (ETC), and doxycycline (DC), in four hospital wastewater effluents and its fate in municipal wastewater treatment plants (WWTPs), in Coimbra, Portugal. Analytical determination was carried out by solid-phase extraction followed by liquid chromatography with fluorescence detection. A gradient system with a mobile phase containing oxalic acid 0.02 M and acetonitrile was used. After postcolumn derivatization with magnesium reagent, TCs were detected at lambda(exc) 386 nm and lambda(em) 500 nm. The proposed method allowed good sensitivity, accuracy, and precision. LOQs were 0.5 microg l(-1) for ETC and TC and 15 and 5 microg l(-1) for MIN and DC, respectively. The recovery values ranged between 66.4% and 117.1%, and intraday and interday repeatability was lower than 6.8%. The method was successfully used to determine the presence of the above-mentioned TCs in 24 wastewater composite samples obtained from hospital effluents and from influent and effluent of the WWTP located in Coimbra, Portugal. MIN and TC were found in 41.7% of the samples; ETC and DC were found in 25% and 8.3% of the samples, respectively. The levels found ranged from 6 to 531.7 microg l(-1) in hospital effluents, while its concentrations in WWTP ranged from 95.8 to 915.3 microg l(-1). A seasonal influence in the concentrations found has also been observed, the levels found in samples collected during spring being higher than those observed in samples collected during autumn; however, these are only preliminary results. The WWTP removal rate ranged between 89.5% and 100%.

On behalf of my co-authors and myself, I would like to thank your comments and those of the reviewers, resulting from a careful reading and review of our paper, "Clinical change in psychopathic traits after an individual compassion focused therapy-based intervention:Preliminary findings of a controlled trial with male detained youth" (JOEX-D-19-00063), which now reads "Clinical change in psychopathic traits after the PSYCHOPATHY.COMP program:Preliminary findings of a controlled trial with male detained youth" (The changing in the title was due to the word limit of the abstract; therefore, for sake of comprehension and coherence, we considered that this new title would be more appropriate). We believe that this review process has contributed to a clear improvement of our work, and are currently submitting its revised and improved version. We are also submitting a response letter detailing how all your concerns and

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Compassion toward others has been defined as the sensitivity to the suffering of others with the genuine commitment to relieve/prevent it. The Compassion Scale (CS) measures this construct and despite its relevance during adolescence, studies have been mostly conducted with adults. This study investigated the psychometric properties of the Compassion Scale-Adolescents (CS-A) in community adolescents (n = 658; 409 girls) and in boys with behavioral disorders (n = 183), from 14 to 18 years old. Results showed the adequacy of a hierarchical-CFA measurement model, with a general score of compassion and four specific factors (i.e., Kindness, Common Humanity, Mindfulness and Indifference). Measurement invariance was tested across samples. Community girls presented higher levels of compassion when compared to boys. Also, behaviorally disturbed boys presented decreased levels of compassion when compared to community boys. Evidence for reliability and construct validity is also provided. The CS-A allows future research between genders in community adolescents. Additionally, future research exploring compassion using the CS-A, between community boys and samples of behaviorally disturbed boys, is now possible.