Background: As the cost of fishmeal continues to rise, there will be a need to optimize the diet by minimizing dietary fishmeal inclusion in aquafeed. In this study, a 7-week experiment was conducted to evaluate soybean meal, fermented soybean meal (soytide), and sesame meal as fishmeal replacers in whiteleg shrimp, Litopenaeus vannamei.Methods: A 30%-based fishmeal diet was considered as control (CON), six other diets were prepared by replacing 20% or 40% of fishmeal with soybean meal (SB 20 and SB 40 ), fermented soybean meal (ST 20 and ST 40 ), or sesame meal (SM 20 and SM 40 ) from the CON diet. Twenty shrimp with average initial weight of 0.65 ± 0.05 g (mean ± SD) were randomly distributed into 21 tanks (45 L) and fed four times a day. Water temperature was controlled at 28 ± 1°C and aeration was provided by air stones. Results: Weight gain, specific growth rate, feed efficiency, and protein efficiency ratio of shrimp fed CON showed no significant differences compared to shrimp fed all the other diets. However, growth performance of shrimp fed ST 20 diet was significantly higher than those of shrimp fed the SM 20 and SM 40 diets (P < 0.05). Superoxide dismutase activity (SOD) of shrimp fed CON, ST 20 , and ST 40 diets was significantly higher than those of shrimp fed the SB 40 and SM 40 diets. But there were no significant differences among shrimp fed CON, SB 20 , ST 20 , ST 40 , and SM 20 diets. Also, lysozyme activity of shrimp fed ST 20 diet was significantly higher than those of shrimp fed the SB 40 and SM 40 diets. Although, lysozyme activity of shrimp fed the CON diet was not significantly different compared to shrimp fed all the other experimental diets. Conclusions: Therefore, SB, ST, and SM could replace 40% of fishmeal based on growth performance and lysozyme. According to the SOD activity, SB and SM could replace 20% of fishmeal and ST could replace 40% of fishmeal in juvenile whiteleg shrimp Litopenaeus vannamei.