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Radioiodine has been used to study the function of the human thyroid gland in various ways. The quantity of radioiodine collected by the thyroid has been determined directly by in vivo measurements (Hamilton, Sole-and co-workers [1][2][3][4]; Hertz and co-workers [5] ), and indirectly by estimations from the total quantity excreted in the urine over a fixed period (Hertz and coworkers [5]; Rawson and co-workers [6,7]). The distribution of iodine in the thyroid has been studied by autoradiograms (3) or by chemical analysis of excised tissue (5). Most recently the capacity of the thyroid to concentrate radioiodide has been studied by Stanley and Astwood (8) after previous administration of an antithyroid drug such as mercaptoimidazol.Keating, Power, Berkson, and Haines (9) have employed radioiodine to investigate the kinetics of iodine metabolism. They studied the urinary excretion of radioiodine by collecting all the urine in short periods for three days or longer. By plotting cumulative urinary excretion against time, they obtained an exponential curve from which were estimated four quantities: (1) a renal fraction (that part of the dose of radioiodine primarily excreted. in the urine); (2) a disappearance rate (which they inferred to represent the proportional rate of disappearance of radioiodine from the blood); (3) a r'enal excretiop rate (the proportional rate of excretion into the urine) ; and (4) a so-called collection rate (the proportional rate of disappearance into other sites than the kidneys, of which the most important is the thyroid). The most significant measure of thyroid activity was the collection rate, which was much less than normal in hypothyroid

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The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.