ObjectiveIdentifying factors associated with depression will help health care providers to design programs which improve quality of services provided to the inpatients. The aim of this study was to assess the prevalence and factors associated with depression among admitted patients at Adare General Hospital, Hawassa, Ethiopia, 2017/2018.ResultThe mean age of the respondents was 38 years (SD ±15.39). The prevalence of depression was 38%. After adjusting for possible confounding variables; age category of 18–24 years [AOR = 1.24, 95 CI (1.08–5.73), having cardiovascular disease [AOR = 2.20), 95 CI (1.38–7.28)] and being in surgical ward [AOR = 1.92), 95 CI (2.13–4.12)] had statistically significant association with depression.