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The simultaneous anti‐inflammatory and ulcerogenic action of non‐steroidal anti‐inflammatory drugs is already well known. The present study was carried out to evaluate the possible effect of talniflumate on the gastric system. Different tests and animal models were used. These included the action on normal and pre‐stressed rats, and, in addition, on animals with experimental ulcers or with increased gastric sensitivity through an aggressive factor. In tolerance tests, with or without stress, the lesion index observed with talniflumate was significantly lower as compared with other compounds. Under simultaneous action of an aggressive agent, talniflumate does not differ from saline solution, used as control. The well defined gastric damage (ulceration and hemorrhage) associated with non‐steroidal anti‐inflammatory drugs was not observed in talniflumate treatments, while pharmacological effect was conserved.

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