No abstract

Glucoprivic responsivity after administration of 500 mg/kg of 2-deoxy-D-glucose (2DG) was evaluated in seven rats adapted to a 0.1% (w/v) quinine-adulterated water supply. Quinine subjects failed to display a significant drug-induced increase in eating, and 2DG actively inhibited their drinking behavior. Significant but reduced glucoprivic responsivity was observed in a larger sample of quinine-adapted animals treated with 250, 500, and 750 mg/kg of 2DG; and the drug once again inhibited quinine fluid intake. These data further suggest the importance of considering hydrational factors in analyzing 2DG effects, although other variables, including palatability-related processes and a quinine x 2DG interaction effect, also appear to be implicated.