RFA using ICE imaging and the CARTO 3 mapping system with contact force measurement is capable of eliminating fluoroscopy in patients undergoing PVI. Exclusion of fluoroscopic imaging does not seem to compromise patient safety and does not affect overall procedure duration, RF application time, or mid-term efficacy.

BackgroundCatheter ablation of persistent atrial fibrillation yields an unsatisfactorily high number of failures. The hybrid approach has recently emerged as a technique that overcomes the limitations of both surgical and catheter procedures alone.Methods and ResultsWe investigated the sequential (staged) hybrid method, which consists of a surgical thoracoscopic radiofrequency ablation procedure followed by radiofrequency catheter ablation 6 to 8 weeks later using the CARTO 3 mapping system. Fifty consecutive patients (mean age 62±7 years, 32 males) with long‐standing persistent atrial fibrillation (41±34 months) and a dilated left atrium (>45 mm) were included and prospectively followed in an unblinded registry. During the electrophysiological part of the study, all 4 pulmonary veins were found to be isolated in 36 (72%) patients and a complete box‐lesion was confirmed in 14 (28%) patients. All gaps were successfully re‐ablated. Twelve months after the completed hybrid ablation, 47 patients (94%) were in normal sinus rhythm (4 patients with paroxysmal atrial fibrillation required propafenone and 1 patient underwent a redo catheter procedure). The majority of arrhythmias recurred during the first 3 months. Beyond 12 months, there were no arrhythmia recurrences detected. The surgical part of the procedure was complicated by 7 (13.7%) major complications, while no serious adverse events were recorded during the radiofrequency catheter part of the procedure.ConclusionsThe staged hybrid epicardial–endocardial treatment of long‐standing persistent atrial fibrillation seems to be extremely effective in maintenance of normal sinus rhythm compared to radiofrequency catheter or surgical ablation alone. Epicardial ablation alone cannot guarantee durable transmural lesions.Clinical Trial RegistrationURL: www.ablace.cz Unique identifier: cz‐060520121617

The optimization of atrioventricular (AV) delay is known to significantly contribute to maximum cardiac performance. The aim of this study was to validate a new, fast, and simple echocardiographic method of identifying the AV delay that provides the maximum cardiac output (CO). Right heart catheterization and Doppler echocardiography of transmitral filling were performed simultaneously in 18 patients with heart failure and at least minimum functional mitral regurgitation treated with atrial synchronized biventricular pacing. CO derived from catheterization and Doppler filling parameters were measured at the predicted optimal AV delay (oAVD), the short AV delay (oAVD - 50 ms), and the long AV delay (oAVD + 28 ms on average/range, +10 ms to +50 ms) during a constant heart rate. The AV delay was regarded as optimal if the end of atrial contraction (represented by the end of A wave of transmitral filling) coincided with the beginning of ventricular contraction (heralded by the onset of the systolic component of mitral regurgitation). Prediction of the optimal AV delay included the following steps: (1) The maximum AV delay at which full ventricular capture is still preserved was found under electrocardiographic control. (2) This value, decreased by 5 to 10 ms, was designated as "the testing long AV delay," and the time interval from the end of the A wave to the onset of the systolic component of mitral regurgitation (time t1) was measured at this setting. (3) oAVD was simply calculated as "the testing long AV delay"- time t1. The CO measured at the oAVD (4.5 +/- 0.7 1. min-1) significantly exceeded those at the short AV delay (4.3 +/- 0.7 1. min-1, P < 0.01) and the long AV delay (4.4 +/- 0.8 1. min-1, P < 0.01), respectively. The method correctly determined the maximum CO in 78% of the patients. In conclusion, Doppler echocardiography enables very rapid and accurate optimization of AV synchrony in patients after the implantation of a biventricular pacemaker.