The regulation of pre-mRNA processing has important consequences for cell division and the control of cancer cell proliferation but the underlying molecular mechanisms remain poorly understood. We report that three splicing factors, SPF45, SR140 and CHERP form a tight physical and functionally coherent complex that regulates a variety of alternative splicing events, frequently by repressing short exons flanked by suboptimal 3' splice sites. These comprise alternative exons embedded in genes with important functions in cell cycle progression, including the G2/M key regulator FOXM1 and the spindle regulator SPDL1. Knockdown of either of the three factors leads to G2/M arrest and to enhanced apoptosis in HeLa cells. Promoting the changes in FOXM1 or SPDL1 splicing induced by SPF45/SR140/CHERP knockdown partially recapitulate the effects on cell growth, arguing that the complex orchestrates a program of alternative splicing necessary for efficient cell proliferation.

This research paper aims to analyse and compare the role of two of the major television networks in international news coverage, Al-Jazeera English and CNN, in relation to one of the most important social movements of the last decade known as the Arab Spring. The study specifically focuses on Egypt during the coup of July 2013, when President-elect Mohamed Morsi was overthrown by the army after weeks of protests. Through a qualitative content analysis based on the framing theory, we will look at the position of both channels regarding a coup emerging from popular uprisings and identify the differences between the two channels. The results show frames matching the definition of conflict (crisis and coup), military power and the legitimacy of democracy. As for divergences, it highlights CNN's stance towards the coup as a necessary evil, while Al-Jazeera English takes a more Islamist approach and prefers to emphasize its democratic legitimacy. The transition to democracy in Egypt is not seen as a linear process of uninterrupted progress, but events such as the coup are seen as slight setbacks in the development of the conflict. These setbacks are a result of the dynamics of power in Egypt, where the military remain in charge above and beyond social movements.

La presente investigación tiene por objetivo analizar y comparar el posicionamiento de dos de las principales cadenas de televisión en cobertura informativa internacional, Al-Jazeera English y la CNN, ante uno de los movimientos sociales más importantes de la última década como han sido las denominadas Primaveras Árabes. El estudio concretamente se centra en Egipto, durante el golpe de estado de julio de 2013, cuando el presidente electo Mohamed Morsi es derrocado por el ejercito tras semanas de protestas. Mediante un análisis de contenido cualitativo, basado en la teoría del framing, comprobaremos cual es la postura de ambas cadenas ante un golpe de estado surgido a raíz de las protestas populares, e identificaremos las diferencias entre ambas cadenas. Los resultados nos muestran encuadres coincidentes como la definición del conflicto (crisis y golpe de estado), el poder militar y la legitimidad de la democracia. En cuanto a divergencias destaca el posicionamiento de la CNN ante el golpe como un mal necesario, mientras Al-Jazeera English se acerca a posturas islamistas enfatizando su legitimidad democrática. La transición hacia la democracia en Egipto no es vista como un proceso lineal de progreso ininterrumpido, sino que hechos como el golpe de estado son vistos como pequeños retrocesos en el desarrollo del conflicto. Estos retrocesos vienen dados por las dinámicas de poder en Egipto, donde el ejército continúa estando al mando muy por encima de los movimientos sociales

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