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Ophiolite assemblages record structural, magmatic, and metamorphic processes that preceded their entrapment in orogenic belts by continental plate collisions. Ophiolite genetic models appealing to ‘oceanic’ or ‘suprasubduction’ provenance are still unable to reconcile several basic problems, including: (1) the association of boninites with oceanic ridge-type structural settings; (2) the diachronous ‘patch-like’ distribution of ophiolites in orogenic belts; (3) disparate ages between and within their mantle and crustal sections; (4) the lack of evidence for ‘obduction’ at modern passive margins. In contrast, the proposal that ophiolite genesis is exclusive to intra-oceanic forearc settings is compelling, given their uniquely shared structural, lithological, and stratigraphic attributes. Forearcs are interpreted to record discrete stages of subduction ‘rollback’ cycles, examples of which begin with subduction nucleation and the formation of boninitic ‘proto-arcs’, followed by arc splitting and concomitant retreat of the evolving arc-forearc complex. Forearc assemblages are likely to resist subduction to become entrapped in orogens, in contrast to denser, recently formed back-arc basin lithosphere, which is reconsumed by subduction following collision of the retreating forearc. As a model for Neo-Tethyan ophiolite genesis, this is predicated on the notion that rollback cycles are driven by ductile asthenosphere mobilized prior to and during collisions of Gondwana fragments with accreting Eurasia. It is also consistent with the apparent correlation of ophiolite ages with collisional events and their conjugate plate kinematic adjustments. Here, we use the slab rollback model as a template for interpreting the structural, magmatic, and metamorphic characteristics of well-studied Tethyan ophiolites, in Albania (Mirdita), Cyprus (Troodos), and Oman (Semail).