The possibility of combining the electronic properties of oligothiophenes with potential chiroptical properties has fueled research in the area of thiaheterohelicenes. Recent reports that these molecules also exhibit fascinating interactions with biologically important macromolecules place further emphasis on the need for new synthetic methods to access thiaheterohelicenes. This review highlights the synthetic methods currently being used to prepare thiaheterohelicenes and discusses the role that chemical synthesis plays in the exploration of the properties of these helically chiral molecules.

Metathesis with a twist! A ring‐closing‐metathesis strategy has been developed for the preparation of various substituted [5]helicene motifs and [6]‐ and [7]helicenes. The two optimized protocols include one method that utilizes the Grubbs second‐generation catalyst under microwave‐irradiation conditions and another that employs a modified Grubbs–Hoveyda catalyst at 40 °C in a sealed reaction vessel. (Mes=mesityl)

Metathese mit Dreh! Die beiden optimierten Ringschlussmetatheseverfahren zur Synthese von substituierten [5]Helicenmotiven sowie von [6]‐ und [7]Helicenen nutzen einmal den Grubbs‐Katalysator der zweiten Generation unter Mikrowellenbestrahlung und einmal einen modifizierten Grubbs‐Hoveyda‐Katalysator bei 40 °C in einem verschlossenen Reaktionsgefäß.

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