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Investigations on lithographically formed cavities of surface-imprinted polymers (SIP) can help to gain deeper understanding on cell recognition with SIPs: it is known that surface topography and biomolecules transferred during...

It is reported on the equilibrium melting point depression of polycarbonate from bisphenol A (PC) in its blend with poly-a-caprolactone (PCL). To this end, a model which explains the bended course of the measured Hoffman-Weeks plots is developed which takes into account the composition changes at the crystal growth front upon progressive crystallization. The occasional melting point depression of the PCL component is discussed. The calculated Flory-Huggins parameter of x12 = -0.09 indicates only weak enthalpic interactions. The remarkable drop in the glass transition temperature of PC with blending allows PC degrees of crystallinity up to 25% upon crystallization from the melt. ZUS AMMENFAS S UNG :Es wird iiber die Gleichgewichts-Schmelzpunktsdepression von Polycarbonat aus Bisphenol A (PC) in Mischungen mit Poly-E-caprolacton (PCL) berichtet. Hierzu wird ein Model1 entwickelt, das den gekriimmten Verlauf der gemessenen Hoffman-Weeks-Plots zu erkliiren vermag. Es beriicksichtigt die Konzentrationsinhomogenitaten, die mit fortscheitender Kristallisation an der Kristallwachstumsfront entstehen. Die gelegentlich beobachtete Schmelzpunktsdepression der PCL-Komponente wird diskutiert. Der Flory-Hugginssche Wechselwirkungsparameter wird zu -0,09 berechnet; aus diesem kleinen Wert mu8 geschlossen werden, dal3 die Mischungspartner enthalpisch nur schwach wechselwirken. Der merkliche Abfall der Glastemperatur des PC nach Einmischen von PCL bewirkt eine betrachtliche Kristallisation aus der Schmelze; es konnen PC-Kristallinitatsgrade bis zu 25% erreicht werden.

Molecularly imprinted polymers (MIPs) come with the promise to be highly versatile, useful artificial receptors for sensing a wide variety of analytes. Despite a very large body of literature on imprinting, the number of papers addressing real-life biological samples and analytes is somewhat limited. Furthermore, the topic of MIP-based sensor design is still, rather, in the research stage and lacks wide-spread commercialization. This review summarizes recent advances of MIP-based sensors targeting biological species. It covers systems that are potentially interesting in medical applications/diagnostics, in detecting illicit substances, environmental analysis, and in the quality control of food. The main emphasis is placed on work that demonstrates application in real-life matrices, including those that are diluted in a reasonable manner. Hence, it does not restrict itself to the transducer type, but focusses on both materials and analytical tasks.

Molecularly imprinted polymers (MIPs) are artificial recognition materials mimicking biological recognition entities such as antibodies. The general model of imprinting assumes that functional monomers interact with functional groups present on...