A novel
series of anticipated biologically active heterocyclic
compounds, such as pyrazole, thiazole, pyridine, acrylamide, thiophene,
triazolo[1,5-a]pyrimidine, imidazolidine, aminopyrazole,
pyrazolo[5,1-c][1,2,4]triazine, triazolo[4,3-a]pyrimidine, benzo[4,5]imidazo[1,2-a]pyrimidine,
pyrido[2′,3′:3,4]pyrazolo[5,1-c][1,2,4]triazine,
isoxazole, benzo[4,5]imidazo[2,1-c][1,2,4]triazine,
pyrimidine, pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidine, pyrano[2,3-d]pyrimidine, and chromene
derivatives, incorporating a sulfonamide-bearing thiazole moiety suitable
to utilize as insecticidal agents were synthesized via a versatile,
readily accessible cyanoacetanilide, 2-cyano-N-(4-(N-(thiazol-2-yl)sulfamoyl)phenyl)acetamide (1).The structures of the newly synthesized compounds were elucidated
by IR, MS, 1H NMR, 13C NMR, distortionless enhancement
by polarization transfer (DEPT), 1H–1H correlation spectroscopy (COSY), heteronuclear multiple bond correlation
(HMBC), and heteronuclear single quantum coherence (HSQC) spectral
analysis. Toxicological and biochemical parameters and biological
aspects of the demonstrated compounds of the synthesized products
against the cotton leafworm, Spodoptera littoralis, under laboratory conditions were also investigated. Regarding the
determined LC50 and LC90 values, sulfonamides
bearing a thiazole moiety, 16a, 8, 28, and 31b, showed the most potent toxic effects
with LC50 values of 49.04, 62.66, 78.62, and 94.90 ppm,
respectively, and toxicity index of 100%, 78.26%, 62.38%, and 51.68%,
respectively.
