Introduction: Androgenetic alopecia (AGA) is hereditary and androgen dependent, progressive thinning of the scalp hair that follows a defined pattern. Aim ot the work: is to evaluate the efficacy and safety of mesotherapy using dutasteride in treatment of androgenetic alopecia in males. Materials and Methods: Ninety male patients were randomly assigned into three groups; group A containing 30 patients who received pure dutasteride, group B of another 30 patients who received dutasteride containing solution and group C of the remaining 30 patients who received saline. Each group was given nine mesotherapy sessions. Assessment was done using trichogram, independent observer assessment of photographs and patients self assessment together with evaluation of possible systemic absorption using semenogram and serum dihydrotestosterone (DHT). Result: Statistical analysis of the thrichogram results, the effect on semenogram and the serum level of dihydrotestosterone.showed that dutastride containing solution was the best. Conclusion: Mesotherapy using dutasteride is a good option for treatment of male pattern hair loss; resulting in reduction or cessation of hair loss and promotion of new hair growth. : Evaluation of the effect of injection of dutasteride as mesotherapeutic tool in treatment of androgenetic alopecia in males. Our Dermatol Online. 2013; 4(1): 40-45

Background: The rapid spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its resulting disease (COVID-19) is one of the greatest global public health crisis of the recent decades. The COVID-19 Biorepository is a national project aimed to support the high demand of biomedical research by multiple groups and the need to have access to high quality, curated clinical data, and specimens contributing to the understanding of, and response to, the COVID-19 pandemic and its impacts in Qatar. Methods/Case presentation: Patients with a laboratory diagnosis of COVID-19, who were Qatar residents that could communicate in Arabic, English, Hindi, and Urdu were eligible to participate in the study. COVID-19 diagnosed patients were recruited at the time of their disease period from the main three public hospitals (Communicable Disease Center, Cuban, and Hazm Mebaireek Hospitals) serving as isolation facilities of symptomatic patients in Qatar, during a 7-month period from March 2020 until September 2020. Consented participants were followed up on a weekly basis until recovery, and then monthly for a year. Sociodemographic and clinical data were collected in electronic questionnaires via a face-to-face interview by trained Qatar Biobank (QBB) staff. Results: A total of 2097 consented participants were recruited up to September 2020, males (N = 1050) and females (N = 1047), with a mean age of 41 years (SD: 15.5). 61.0% of the participants had at least one follow up while 27% adhered to monthly follow up visits. Data was collected for 99.7% of the participants, while the follow up process is still ongoing. In total there are 107,171 high quality specimens in the biorepository including plasma, erythrocytes, buffy coat, serum, PAXgene whole blood, nasopharyngeal secretions, and DNA. Conclusion: The COVID-19 Biorepository is a national asset to illuminate the pathophysiological and identify markers of disease prognosis as well as to describe the clinical features and epidemiology of COVID-19 in Qatar and worldwide.

Background: Infant regurgitation is the most prevalent functional gastrointestinal disorder in infancy. Knowing the benign outcome of such condition helps to decrease the anxiety of parents and unnecessary prescriptions by physicians. Objectives: The aims of the current work were to detect the outcome of infant regurgitation among Egyptian infants diagnosed by Rome Ⅳ criteria and to detect its prevalence among the surveyed population. Patients and Methods: A prospective cohort study enrolling 280 healthy infants 1-4 months diagnosed as infant regurgitation according to Rome Ⅳcriteria by fulfilling a questionnaire and undergoing examination. Parents were reassured and educated then both were repeated after 3 months. According to the outcome, infants were divided into symptomatic infants, who were either partially improved or not-improved at all and asymptomatic infants who had stopped regurgitation. Results: The prevalence of regurgitation was 20.3% among the surveyed 1380 infants. On follow up 42.9% of infants became asymptomatic while 49.6% partially improved and only 7.5% didn't improve. Weight was properly gained for all patients except 3 who had failure to thrive, however that was not correlated with the outcome of regurgitation. Proton pump inhibitors were prescribed for 7.7% of cases, however, increasing age was the only predictor of total improvement after 3 months follow up with odds ratio=2.45 and confidence interval (1.57-3.84). Conclusion: Infant regurgitation diagnosed according to Rome Ⅳ criteria seems to be normal behavior in early infancy which resolves by time, just requiring parental , reassurance, and follow up, while no interventions are needed.

Background: During the COVID-19 outbreak, Qatar Biobank (QBB) adapted its services to collect, process, and store high-quality data and specimens. This transformation period brought opportunities, risks, and challenges. Methods: QBB holds College of American Pathologists (CAP) accreditation and International Organization for Standardization (ISO) certification for Quality Management (9001:2105) and Information Security Management Systems (27001: 2013). These standards helped to effectively convert its operations to facilitate the COVID-19 national project. The COVID-19 Biorepository is a National Disease-based study aiming to collect adequate health information and biological samples from Qatar residents infected by SARS-CoV-2 virus to enable evidence-based research towards the discovery and development of novel healthcare interventions and to facilitate research projects related to the COVID-19 pandemic. QBB IT Department used open-source Onyx (ObiBa) software to newly develop a COVID-19 electronic system and interface for various clinical devices and Laboratory Information Management System. QBB operational services were adapted to accommodate the COVID-19 project by providing training to the personnel (n = 20; i.e. nurses, research assistants etc.) and developing work instructions (n>5) for the participants’ recruitment process, data and specimen collection in the different hospitals. A COVID-19 portal was also developed by QBB to facilitate data access for researchers from Qatar and worldwide. Results: Within 5 weeks QBB transformed to accommodate a disease/virus-based biorepository. At an operational level, multi-adjustments were implemented. QBB IT department developed an electronic system for the data collection and specimen traceability. Clinically trained staff were transferred to different healthcare facilities to recruit COVID-19 positive patients. QBB laboratory designed special collection kits. QBB Medical Review Office and Scientific and Education departments managed the recruitment process, set up of the study and provided training to the staff. The Communications and Participants Recruitment Department transformed its operations to fit the needs of the COVID-19 initiative. The Research Access Office designed the COVID-19 access portal and supported the project through purchasing of personal protective equipment and other administrative tasks. Conclusion: It is now time to consider lessons learned, as many countries have been affected by this pandemic, and to understand that biobanks are an asset for a country and there is a need to integrate them into a new standard with their sustainability in mind. Qatar Biobank is a good showcase of how a biobank can successfully assist in the collection of important data related to different health crises such as the COVID-19 pandemic.