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The voltammetric behavior of Thyroxine (T 4) was studied using square wave voltammetry in phosphate buffer solution at (pH 7.0) as supporting electrolyte. Thyroxine gives two well-defined reduction peaks at Ep 1 (-0.359) volt and Ep 2 (-1.01) volt verses (Ag/AgCl/Sat.KCl) as reference electrode. The Gibb`s free energy (∆G), enthalpy (∆H) and entropy (∆S) changes of temperature dependent on (K) were calculated using Van`t Hoff equation for Thyroxine and Uracil binding. The molecular docking between Thyroxine and Uracil has been studied, and the results indicate that the interaction between T 4 and Ur was mainly hydrogen bonding and van der Waals interaction.

The voltammetric behavior of Thyroxine (T 4) was studied using square wave voltammetry in phosphate buffer solution at (pH 7.0) as supporting electrolyte. Thyroxine gives two well-defined reduction peaks at Ep 1 (-0.359) volt and Ep 2 (-1.01) volt versus the reference electrode (Ag/AgCl/Sat.KCl). The calibration curve is linear within a two range of concentration, first is (1.996x10-7-19.61x10-7)M with the R 2 equal to (0.999) and (0.9963) for Ep 1 and Ep 2 respectively, and second (0.996x10-6-11.857x10-6) M with the R 2 equal to (0.9819) and (0.9848) for Ep 1 and Ep 2 respectively. The Gibb`s free energy (∆G), enthalpy (∆H) and entropy (∆S) changes of temperature dependent on (K) were calculated using Van`t Hoff equation for Thyroxine and Thiourea binding. The molecular docking between Thyroxine and Thioureahas been studied, and the results indicates thatthe interaction between T 4 and TU was mainly hydrogen bonding and van der Waal`s interaction.