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Background: Immunological gene and serum level for interleukin-9 rs 17317275 have been established to have linked to predisposition systemic lupus erythematosus (SLE) and its severity. SLE is a severe, systemic autoimmune disease characterized by autoantibody generation, complement activation, and immune complex deposition. In the pathophysiology of SLE, cytokines have a pleiotropic function. Recently, IL-9 was discovered to mediate strong antiinflammatory effects in numerous cells or experimental autoimmune models.Objective: This study aimed to determine the role of age, IL-9 serum level and genetic polymorphism, C-reactive protein (CRP), Anti-nuclear antibody (ANA) and Anti-double-stranded DNA (anti-dsDNA) to recognize SLE pathogenesis. Materials and Methods: This case-control study was carried out in Baghdad Teaching Hospital and Typical Rheumatology Unit through the period from October 2021 to January 2022.103 Iraqi patients with SLE illness and 50 healthy Iraqis were included. Blood samples were taken. Serum IL-9 levels measured using the sandwich enzyme-linked immune-sorbent assay technology (ELISA) and cytokine genotyping by using allele-specific PCR technique Results: SLE groups had greater levels of IL-9 than did healthy volunteer. Furthermore, both autoantibodies (ANA, Ant-dsDNA) were positive in SLE patients. The findings indicated that CRP was much higher in SLE subjects than those of healthy controls. On the other hand, the results showed that there was non-significance (p-value > 0.05) in age of studied groups. Concerning genotyping frequencies, the GG and AG genotyping were greater in the SLE group compared to the healthy subjects, while the AA genotyping frequency was significantly lower in the SLE group compared to the healthy people. Conclusion: This study indicated the major roles of the serum level and genetic polymorphism of IL-9, CRP, ANA and anti-ds DNA in pathogenesis and severity of SLE.

Metal foam has found its way in many engineering industries due to its ability to improve the heat transfer rate in thermal applications. Thermal energy storage based on phase change materials (PCMs) have significant importance as a part of renewable energy sources, and thermal management applications, However, low thermal conductivity is the essential drawback associated with the PCMs, especially the organic type of it, such as paraffin. Various experimental and numerical studies performed to test the effect of using metal foam with PCMs, in order to improve PCMs thermal conductivity. Many models suggested for evaluating the effective thermal conductivity of high porosity open cells metal foam, which immersed in base fluids of low thermal conductivity such as air, water, and PCMs. This work achieved numerically by using different models for calculating the effective thermal properties of metal foam with various range of porosities impregnate in paraffin. The study discussed the temperature distribution, which control the heat transfer rate, the behavior of temperatures versus time, and improvements in the melting front phase of the paraffin, under the effect of copper metal foam of various porosities and by applying different models, for estimating the effective thermal conductivity. The results exhibit an augmentation in the effective thermal conductivity with porosity decreasing. The outputs showed paradoxical results using the presented models and the differences between them have been discussed.