Developing successful sign language recognition, generation, and translation systems requires expertise in a wide range of fields, including computer vision, computer graphics, natural language processing, human-computer interaction, linguistics, and Deaf culture. Despite the need for deep interdisciplinary knowledge, existing research occurs in separate disciplinary silos, and tackles separate portions of the sign language processing pipeline. This leads to three key questions: 1) What does an interdisciplinary view of the current landscape reveal? 2) What are the biggest challenges facing the field? and 3) What are the calls to action for people working in the field? To help answer these questions, we brought together a diverse group of experts for a two-day workshop. This paper presents the results of that interdisciplinary workshop, providing key background that is often overlooked by computer scientists, a review of the state-of-the-art, a set of pressing challenges, and a call to action for the research community.Each group focused on the following questions:

Answer ALS is a biological and clinical resource of patient-derived, induced pluripotent stem (iPS) cell lines, multi-omic data derived from iPS neurons and longitudinal clinical and smartphone data from over 1,000 patients with ALS. This resource provides population-level biological and clinical data that may be employed to identify clinical–molecular–biochemical subtypes of amyotrophic lateral sclerosis (ALS). A unique smartphone-based system was employed to collect deep clinical data, including fine motor activity, speech, breathing and linguistics/cognition. The iPS spinal neurons were blood derived from each patient and these cells underwent multi-omic analytics including whole-genome sequencing, RNA transcriptomics, ATAC-sequencing and proteomics. The intent of these data is for the generation of integrated clinical and biological signatures using bioinformatics, statistics and computational biology to establish patterns that may lead to a better understanding of the underlying mechanisms of disease, including subgroup identification. A web portal for open-source sharing of all data was developed for widespread community-based data analytics.

The clinical presentation of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, varies widely across patients, making it challenging to determine if potential therapeutics slow progression. We sought to determine whether there were common patterns of disease progression that could aid in the design and analysis of clinical trials. We developed an approach based on a mixture of Gaussian processes to identify clusters of patients sharing similar disease progression patterns, modeling their average trajectories and the variability in each cluster. We show that ALS progression is frequently nonlinear, with periods of stable disease preceded or followed by rapid decline. We also show that our approach can be extended to Alzheimer’s and Parkinson’s diseases. Our results advance the characterization of disease progression of ALS and provide a flexible modeling approach that can be applied to other progressive diseases.

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