Ocular, respiratory, and systemic symptoms on the evening of October 5, 2005, corresponded to a plume of chloropicrin, with estimated concentrations as high as 0.15 ppm, in the community of Salinas, California. Cases occurred between 0.36 and 2.89 miles from the application site. Use of irritant agricultural fumigants near residential neighborhoods can produce a risk of illness for distances more than 2 miles from the site of application. Air modeling is useful for evaluating the relationship between possible exposures and community symptoms.