While bottom-up synthetic strategies for the formation of near-monodisperse clusters have attracted much attention, top-down synthetic strategies in which metals are dispersed into clusters can also be viable. In this...

No abstract

An efficient, environmentally benign, and simple one-pot approach to the synthesis of 5-(iodomethyl)thiazolidine-2-thiones via multicomponent reaction of allylamines, carbon disulfide, and iodine under solvent-free conditions is presented. The obtained 5-(iodomethyl)thiazolidine-2-thiones were converted into silyl-protected terminal [(ethynylthio)methyl]-substituted thiazolidine-2-thiones by treatment with lithium 2,2,2-tris(trimethylsilyl)ethanedithioate, produced by the reaction of tris(trimethylsilyl)methyllithium with carbon disulfide.

Oxidised copper nanoparticles on TiO2 have been found to effectively catalyze the multicomponent synthesis of 1,4-disubstituted 1,2,3-triazoles in water under both conventional heating and ultrasonic irradiation conditions. The Cu/TiO2 nanocatalyst is easy to prepare, very versatile and recyclable. Following the optimized conditions, an array of 1,2,3-triazoles containing thiazolidine-2-thiones were synthesized from 5iodomethylthiazolidine-2-thiones, sodium azide, and phenylacetylene. All the compounds were evaluated for antibacterial activitiy and some of them displayed varying levels of antibacterial activity against Staphylococcus aureus and Escherichia coli.

No abstract