Objectives This study aimed to evaluate the influence of different salivary pH on flexural strength, hardness, and surface roughness of computer-aided design and computer-aided manufacturing (CAD/CAM) milled and three-dimensional (3D)-printed denture base resins. Methods One heat-polymerized, two CAD/CAM milled (IvoCad, AvaDent), and two 3D-printed (FormLabs, NextDent) denture base resins were fabricated and divided into five groups (n = 10) according to the solutions: three groups were immersed in different salivary pH (5.7, 7.0, or 8.3), one group was immersed in distilled water (DW) as a positive control, and one group had no immersion (negative control). All immersions were performed at 37°C for 90 days. Flexural strength, hardness, and surface roughness were measured before and after immersion. Data was analyzed with analysis of variance and post hoc Tukey's test (α = 0.05). Results After immersion, all specimens had lower flexural strength values when compared with those with no immersion. Comparing the immersion groups, the highest flexural strength value (93.96 ± 3.18 MPa) was recorded with IvoCad after immersion in DW while the lowest value (60.43 ± 2.66 MPa) was recorded with NextDent after being immersed in 7.0 pH saliva. All specimens had significant decrease in hardness except IvoCad and AvaDent specimens where both presented the highest surface hardness (53.76 ± 1.60 Vickers hardness number [VHN]) after immersion in DW while NextDent showed the lowest hardness value (24.91 ± 2.13 VHN) after being immersed in 8.3 pH saliva. There was statistically significant difference between the baseline and different artificial salivary pH solutions in terms of surfaces roughness, with the highest surface roughness were found in 3D-printed resin materials. Conclusion After exposure to artificial saliva with different salivary pH, the milled CAD/CAM denture base resins showed higher flexural strength, hardness, and lesser surface roughness than conventional and 3D-printed denture base resins.

Salivary pH is a neglected factor that may affect the performance of removable dental prostheses (RDP). This study aimed to review literature in reference to the role of salivary pH on the performance of RDP and materials used for their fabrication. From January 1990 until December 2021, a search was done on PubMed, Scopus, and Web of Science databases using removable dental prostheses, salivary pH, PMMA, Denture base, and physical properties as keywords. Articles that met the inclusion criteria (full-length articles have investigated the effect of salivary pH on RDP materials in vitro and in vivo) were included. Out of 433 articles, 8 articles that met the inclusion criteria were included. All studies used artificial saliva with different salivary pH ranging between 3 and 14. Two articles investigated the role of salivary pH on the cytotoxicity of denture base resins and soft liner. One article studied the durability and retention of attachments, one article analyzed the performance of PEEK materials, one article researched the fatigue resistance of a denture base, one article investigated the corrosion of RPD framework cast and milled Co–Cr, one article studied the strength and clasp retention and deformation of acetal and PEEK materials, and one evaluated changes in mass and surface morphology of CAD–CAM fiber-reinforced composites for the prosthetic framework. Different salivary pH affected all included materials in this review except PEEK materials. The most adverse effect was reported with alkaline and acidic; however, the acidic showed the most deterioration effect. Salivary pH has a role in the selection of material used for RDP fabrication.