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Background: Iodine-131 therapy is one of the main strategies in the treatment of thyroid diseases such as hyperthyroidism and thyroid cancer. Iodine-131 emits high-energy beta particles and gamma rays. Although this technique is considered safe, there are many in vivo and in vitro studies reporting genotoxic damage induced by I-131. Induction of oxidative stress is one of the main mechanisms of therapeutic plan with I-131 and also mentioned as a side effect of it. Objectives: The aim of this study was to determine the effect of Nano-curcumin on chromosomal damages in peripheral blood lymphocyte by micronuclei (MN) assay in patients with differentiated thyroid carcinoma (DTC) after therapeutic dose of I-131 as a clinical trial. Methods: Twenty-one patients with DTC treated with I-131, activity (5.5 GBq) for destructing remnant thyroid functional tissue, were randomly selected to receive curcumin (nano-form, 160 mg/day for 10 days; n = 11) or placebo (n = 10) in a double-blind manner. We obtained blood samples from each patient before treatment and one week after radioiodine therapy. We calculated the number of MN in blood samples. The present study is the first clinical trial for investigating curcumin effectiveness to reduce genotoxicity effects by radiation after radioiodine therapy. Results: The frequency of MN in lymphocyte was significantly increased at one week after I-131 treatment in placebo and curcumin groups. The frequency of MN in the curcumin group was significantly lower than placebo group after I-131 therapy. Nevertheless, there were no significant differences between both groups in White Blood Cell (WBC), Red Blood Cell (RBC), platelets, and hemoglobin level at before and after I-131 therapy. Conclusions:The results of this study confirm that the administration of curcumin to the patients, in nano-micelle form, may prevent the genetic damage induced by I-131 in human lymphocyte.

Background: Depression is one of the most common psychiatric problems in hemodialysis patients. Objectives: This study aimed to evaluate the effect of cool dialysate on depression in patients with chronic renal failure treated with hemodialysis. Methods: This randomized clinical trial was performed on 66 hemodialysis patients suffering from depression. Patients were selected by a convenience sampling method and divided equally into intervention and control groups randomly by permuted block allocation, each group containing 33 patients. Data were acquired with the Beck Depression inventory-I. The intervention and control groups underwent one month of treatment with cool dialysate at 35.5 and 37°C, respectively. The severity of depression for each group was measured at the end of each treatment stage and two weeks after the intervention. Data were analyzed using R version 25 software with a confidence level of 95%. Results: There was no statistically significant difference between the control and intervention groups before and after the intervention (P-values more than 0.05). While the mean of depression severity for the control group decreased from 26.15 ± 1.46 to 22.24 ± 2.00 (P-values < 0.01), the mean of depression severity for the intervention group decreased from 25.56 ± 1.28 to 22.41 ± 1.65 by the intervention (P-value > 0.05). Conclusions: The application of cool dialysate as a non-pharmacological method did not significantly reduce the severity of depression in patients undergoing hemodialysis. Therefore, it is advised to perform further studies that include more research units from different geographical locations, considering a longer intervening duration.

BackgroundThe increase in intestinal permeability following damage to the intestinal mucosa in any surgical procedure, trauma or fasting is well- known.ObjectivesOur objective was to experimentally evaluate whether antioxidant consumption is associated with decreased intestinal damage in intestinal surgical procedures.Materials and MethodsForty rabbits were used to compare the pathological changes in the intestine after consumption of dextrose water 5% (D5W), black tea and orange juice in fasting and in cases with intestine resection and anastomosis. They were divided in to five groups as shams (GI), NPO (G II), D5W (GIII), black tea (GIV) and orange juice groups (GV). In GII to GV group with median laparotomy, a 2 cm segment of jejunum was resected and ends of the bowel were anastomosed. Postoperatively, animals fasted for five days. Animals in GII were killed after five days of fasting. On day five case groups were given free access to drinking D5w (GIII), black tea solution (G IV) and orange juice (GV) for a further 7 days. On day 8, animals were reoperated and the repaired segment of intestine was removed. Morphologic data were compared in groups.ResultsThere were 8 rabbits in each group. There was a significant difference in villi lengths in the groups (P = 0.003). GV rabbits had obvious recovery of the villous architecture.ConclusionsOrange juice as a source of vitamin C may be an appropriate liquid for postoperative recovery following intestinal surgery.