The one-pot, three-component reaction between aryl aldehydes, 2-naphthol, and acetonitrile in the presence of chlorosulfonic acid affords 1-[acetylamino(aryl)methyl]-2-naphthols in excellent yields.
An improved four-component reaction of isocyanides is described. The reaction between alkyl isocyanides, dialkyl acetylenedicarboxylates, aromatic amines and benzoic acid in dichloromethane at room temperature leads to dialkyl 2-benzoyloxy-3-(N-alkyl-N′-arylcarbamimidoyl)succinates in good yields
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