Introducing nanotechnology in concrete is one of the most significant successes in enhancing the mechanical properties of concrete. It affects the quality of the microstructure of the concrete due to its extremely small nanoparticles leading to a faster reaction due to its large surface area. The nanoparticles fill the concrete's pores, resulting in considerably improved strengths in the early ages of the concrete. This research used six models; linear regression (LR), multilinear regression (MLR), nonlinear regression (NLR), pure quadratic (PQ), interaction (IA), and full quadratic (FQ), to predict the compressive strength of the concrete modified with different Nanosilica contents for various mix proportions. The models were applied to three datasets, with 420 collected from several research studies. The ranges of the concrete mix proportions used in this study were as follows, water/cement ratio (w/c) ranged between 0.1 and 1, cement content (C) ranged between 153.81 and 1200 kg/m3, fine aggregate content (FA) ranged between 492 and 2270 kg/m3, coarse aggregate content (CA) ranged between 617 and 2900 kg/m3, superplasticizer (SP) ranged between 0% and 6.7%, coarse aggregate size (CAS) ranged between 6 and 50.8 mm, fine aggregate size (FAS) ranged between 0.025 and 10 mm, Nanosilica content (NS%) ranged between 0% and 15%, w/c of 0.4–0.6 and the curing time (days) ranged between 3 and 180. The compressive strength of the collected datasets ranged from 3 to 120 MPa. The parameters that have improved the analyzed datasets of the compressive strength were the content of Nanosilica and the SP. The models were assessed for their accuracy using multiple assessment criteria; the most evident ones are; the objective function (OBJ), root mean square error (RMSE), Scatter Index (SI), and the maximum absolute error (MAE). The analytical models and the model comparison operations will be shown in detail in this research, indicating that the most effective and accurate model is the FQ model; where coefficient of determination (R2) of 0.96, RMSE of 3.49 MPa, MAE of 2.96 MPa, and SI of 0.08 were conducted from the analytical studies. From the developed models, the compressive strength of the concrete up to a high compressive strength level with high accurately can be predicted. Also, the compressive strength of the concrete can be accurately predicted for various sizes of aggregate and specimens.
