Recently, the development of carbon nanocomposites composed of carbon nanotubes and metal nanoparticles has attracted many interests because of their large potential for technological applications such as catalysts, sensors, biomedicine, and disinfection. In the present study, we described a simple chemistry method to synthesize multi‐walled carbon nanotubes (MWCNTs) decorated with silver nanoparticles (Ag‐NPs). Also, we investigated the antioxidant and anti‐acute leukemia activities against acute myeloid leukemia and acute T cell leukemia cell lines. Ag NPs‐MWCNTs were characterized and analyzed using common nanotechnology techniques including transmission electron microscopy (TEM), X‐ray diffraction (XRD), energy dispersive X‐ray spectroscopy (EDS), field emission‐scanning electron microscopy (FE‐SEM) and elemental mapping analysis. Also, 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) test was performed to assess the antioxidant capacities of AgNO3, MWCNTs, and Ag NPs‐MWCNTs. It revealed similar antioxidant potentials for Ag NPs‐MWCNTs and butylated hydroxytoluene. In MTT assay, Ag NPs‐MWCNTs had very low cell viability (very high anti‐acute leukemia properties) dose‐dependently against 32D‐FLT3‐ITD (Acute myeloid leukemia cell line), Human HL‐60/vcr (Acute myeloid leukemia cell line), Jurkat, Clone E6–1 (Acute T cell leukemia cell line), and J.RT3‐T3.5 (Acute T cell leukemia cell line) without any cytotoxicity on human umbilical vein endothelial cell line (HUVEC; Normal cell line). In conclusion, the synthesized Ag NPs‐MWCNTs revealed excellent antioxidant and cytotoxicity activities against acute myeloid leukemia and acute T cell leukemia cell lines in a dose depended manner. After confirming in the in vivo and clinical trials, these nanoparticles can be administrated in humans for the treatment of acute leukemia especially acute myeloid leukemia and acute T cell leukemia.

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Background With regards to applicative, facile, green chemical research, a bio-inspired approach is being reported for the synthesis of Au nanoparticles by using Mentha pulegium flower extract. Methods The phytochemical immobilized Au NPs were characterized by advanced physicochemical techniques like Fourier Transformed Infrared spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy Dispersive X-ray spectroscopy (EDX), and X-ray Diffraction (XRD) study. Thereafter, catalytic performance of those biomolecule functionalized Au NPs was investigated in the efficient reduction of nitroarenes over a range of substrates. To survey the anti-human colon cancer effects of gold nanoparticles, MTT assay was used on the common colon cancer cell lines i.e., colorectal adenocarcinoma (HT-29), colorectal carcinoma (HCT 116), ileocecal colorectal adenocarcinoma (HCT-8 [HRT-18]), and Burkitt's lymphoma (Ramos.2G6.4C10). Results The conversion was achieved in short reaction time with good to excellent yields in association with outstanding turnover frequency (TOF). In addition, the nanocomposite catalyst was easily recovered and recycled for 12 successive times without noticeable decrease in catalytic activity. Gold nanoparticles had high anti-colon cancer activities dose-dependently against HT-29, HCT 116, HCT-8 [HRT-18], and Ramos.2G6.4C10 cell lines. The best result of anti-colon cancer effects was seen in the case of the HCT 116 cell line. Conclusions It looks gold nanoparticles can be used for the treatment of several types of colon cancers in human.

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Objective The current study is the first experimental study of which has evaluated the MICs and MBCs of ZnONPs, MgONPs, and mixture MgONPs-ZnONPs against H 37 Rv Mtb and MDR-Mtb.Results The MIC of MgONPs and ZnONPs were 0.195 and 0.468 µg.ml -1 against 10 4 of H 37 Rv Mtb. As well, 0.166 µg.ml -1 of MgONPs-ZnONPs was able to inhibit 10 -4 H 37 Rv Mtb. The MIC of MgONPs against 10 4 concentrations of MDR-Mtb was 12.5 µg.ml -1 . The MIC of MgONPs/ZnONPs against 10 4 concentrations of MDR-Mtb reached to 0.664 µg.ml -1 . Based on the results, the MBC value of ZnONPs increased to 1.875 µg.ml -1 against 10 -4 concentrations of MDR-Mtb. Testing showed that the MBCs of MgONPs/ZnONPs reached to 1.328 µg.ml -1 against 10 4 concentrations of MDR-Mtb. The half maximal inhibitory concentration (IC50) against MDR-TB was 0.779 µg.ml -1 for ZnONPs and 0.883 µg.ml -1 for MgONPs-ZnONPs. The MgONPs-ZnONPs was not toxic to Vero cell lines however ZnONPs could inhibit the Vero and HepG 2 cell lines. We found that ZnONPs and mixture MgONPs-ZnONPs not only have higher bactericide behavior but might have also synergistic effects against MDR-TB.