Background: Along with growth of attention to spirituality in workplace, this question "what is the meaning and effects of spirituality in workplace" came up. Objectives: To investigate the relationship between spirituality in a workplace, organizational commitment, and professional ethics among girl senior high school teachers in Neka city-Iran. Methods: A sample of 90 teachers who had 5 years of experience of teaching participated in a descriptive-relational study. Data gathering process was done using spirituality in workplace, organizational commitment, and professional ethic questionnaires. Pearson Correlation Coefficient tests were used for data analysis. Results: There was a significant relationship between spirituality in workplace and dimensions of organizational commitment and professional ethics [(r = 0.556, 0.482, 0.328 n = 90, P = 0.000), (r = 0.570, 0.375, 0.318, 0.356 n = 90, P = 0.000) respectively]. Also, there was a significant correlation between spirituality in workplace, organizational commitment and professional ethics (r = 0.466, 0.449, n = 90, P = 0.000). Conclusion:The more spirituality in the work place among teachers would cause a growth in organizational commitment and professional ethics and vice versa. Accordingly, educational organizations need to pay attention to teachers' mental and spiritual needs, so they can do their jobs with perseverance, commitment, and seriousness.