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Background. The upper airway volume is among the factors that affect orthodontic treatment plans. Cone-beam computed tomography (CBCT), as an accurate diagnostic modality, can help assess anatomical structures associated with the upper airway volume.Objectives. This study aimed to use CBCT to determine if there are differences in the upper airway volume between different sagittal and vertical skeletal patterns, considering the hyoid bone position, palatal depth, nasal septum deviation (NSD), and concha bullosa. Material and methods.From among 105 initial CBCT samples retrieved from the archive of a private radiology clinic in Tehran, Iran, 90 CBCT scans of 27 males and 63 females aged 17-65 years were considered in the study according to the inclusion criteria. The upper airway volume was assessed with regard to Angle's classification (using the A point-nasion-B point angle (ANB)), the vertical skeletal dimension (using the sella-nasion plane to mandibular plane angle (SN-MP)), the hyoid bone position, palatal depth, NSD, and concha bullosa, using CBCT and the NNT ® software. The one-way analysis of variance (ANOVA), Levene's test and the t test were used to analyze the data with the SPSS Statistics for Windows software, v. 17.0.Results. The upper airway volume was significantly smaller in long-face cases (p = 0.037). There was no significant correlation between the upper airway volume and Angle's classification, the hyoid bone position, palatal depth, NSD, and concha bullosa.Conclusions. The vertical skeletal dimension was the only parameter that was related to the upper airway volume. The results of this study can be considered while preparing orthodontic treatment plans.