Nanocomposites α-Fe/Fe3B/Y2O3 were prepared by a melt-spun technique, and the electromagnetic wave absorption properties were measured in the 0.05–20.05 GHz range. Compared with α-Fe/Y2O3 composites, the resonance frequency (fr) of α-Fe/Fe3B/Y2O3 shifted to a higher frequency range due to the large anisotropy field (HA) of tetragonal Fe3B (∼0.4 MA/m). The relative permittivity (εr=εr′−jεr″) was constantly low over the 0.5–10 GHz region, which indicates that the composite powders have a high resistivity (ρ=∼100 Ω m). The effective electromagnetic wave absorption (reflection loss <−20 dB) was obtained in a frequency range of 2.7–6.5 GHz on resin composites of 80 wt % α-Fe/Fe3B/Y2O3 powders, with thickness of 6–3 mm, respectively. A minimum reflection loss of −33 dB was observed at 4.5 GHz with an absorber thickness of 4 mm.
Traditionally, surgical training meant on-the-job training with live patients in an operating room. However, due to advancing surgical techniques, such as minimally invasive surgery, and increasing safety demands during procedures, human cadavers have been used for surgical training. When considering the use of human cadavers for surgical training, one of the most important factors is their preservation. In this review, we summarize four preservation methods: fresh-frozen cadaver, formalin, Thiel's, and saturated salt solution methods. Fresh-frozen cadaver is currently the model that is closest to reality, but it also presents myriad problems, including the requirement of freezers for storage, limited work time because of rapid putrefaction, and risk of infection. Formalin is still used ubiquitously due to its low cost and wide availability, but it is not ideal because formaldehyde has an adverse health effect and formalin-embalmed cadavers do not exhibit many of the qualities of living organs. Thiel's method results in soft and flexible cadavers with almost natural colors, and Thiel-embalmed cadavers have been appraised widely in various medical disciplines. However, Thiel's method is relatively expensive and technically complicated. In addition, Thiel-embalmed cadavers have a limited dissection time. The saturated salt solution method is simple, carries a low risk of infection, and is relatively low cost. Although more research is needed, this method seems to be sufficiently useful for surgical training and has noteworthy features that expand the capability of clinical training. The saturated salt solution method will contribute to a wider use of cadavers for surgical training.
T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF-α and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential roles in various inflammatory diseases, such as experimental autoimmune encephalomyelitis, rheumatoid arthritis, colitis, and Concanavalin A-induced hepatitis. In this review, we summarize the characteristics of the functional role of Th17 cells, with particular focus on the Th17 cell-related cytokines such as IL-17, IL-22, and IL-23, in mouse models and human inflammatory diseases.
The CRISPR/Cas system, in which the Cas9 endonuclease and a guide RNA complementary to the target are sufficient for RNA-guided cleavage of the target DNA, is a powerful new approach recently developed for targeted gene disruption in various animal models. However, there is little verification of microinjection methods for generating knockout mice using this approach. Here, we report the verification of microinjection methods of the CRISPR/Cas system. We compared three methods for injection: (1) injection of DNA into the pronucleus, (2) injection of RNA into the pronucleus, and (3) injection of RNA into the cytoplasm. We found that injection of RNA into the cytoplasm was the most efficient method in terms of the numbers of viable blastocyst stage embryos and full-term pups generated. This method also showed the best overall knockout efficiency.
Fe nanowires with 70–200nm in diameter and 20–50μm in length were synthesized by a chemical vapor deposition method for electromagnetic wave absorption application. The frequency dependences of relative permittivity (εr) and permeability (μr) were strongly dependent on the diameter of Fe wires. Compared with micrometer wires or flakelike samples, nanowires exhibited a magnetic resonance (μr″) peak in the range of 1–18GHz, suggesting that nanowires have significant effect for reducing the eddy current loss, therefore, the resin compacts of 29vol% Fe nanowires with thicknesses of 1.3–4.0mm provided good electromagnetic wave absorption performances in the range of 5.6–18GHz.
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