No abstract

Severe osteoporosis and some myelofibrosis of the alveolar bone developed in rats fed a citrate diet. The administration of coenzyme Q7 alleviated these histopathologic effects. It was also demonstrated that hypercitricemia with hypercalcemia found in the citrated rats were significantly restored to normal levels by coenzyme Q, administration.

Effect of coenzyme Q administration on the periodontal lesions in citrated ratsToshiharu MATSUMURA, Masahiro KIMATA, Akira TSUNEMITSU and Masatoyo AKIYOSHI Citrate may play a role in the transport, mobilization and perhaps deposition of calcium in bone. It is capable of rendering soluble the insoluble calcium salts. Tanner(1967) has observed that citrated rats disclosed severe porosity with alveolar atrophy and myelofibrosis accompanied by bone resorption and hyperemia of the gingiva. This indicated citrates to be directly attributed to loss of alveolar bone and intimately related to advanced alveolar atrophy .This study was designed to confirm the histopathological changes in periodontal tissues in citrated rats and simultaneously to evaluate the calcium and citrate levels in blood. Since it