SummaryThe effects of prenatal triethylene tetramine dihydrochlo ride (Trien-2HCl) exposure on fetal mice have been investigated on gestational day 19. Trien-2HCl was given throughout pregnancy at levels of 0 (control), 3,000, 6,000, or 12,000ppm as drinking water, ad libitum. At the level of 12,000ppm, the frequency of total resorption tended to be high and that of fetal viability tended to be low, as compared to controls. Decreased maternal weight was observed in body, but not in liver, at the level of 12,000ppm. Fetal body and cerebrum weights significantly decreased at the levels of 6,000 and 12,000ppm; however, fetal liver weight remained unchanged. Maternal serum copper concentration was not affected by the Trien-2HCl. Fetal copper concentrations of liver and cerebrum were significantly lower in the Trien-2HCl-treated groups than in the controls, with levels decreasing in a dose-related manner. When the copper and zinc concentrations in the group treated at 12,000 ppm were compared with those in controls, significant decreases in both metals were observed in placenta but not in maternal liver. Changes in fetal zinc concentration varied by tissues: i.e., an increase in liver and no change in cerebrum. Fetal abnormalities were frequently observed in brain, and the frequency was increased with increasing levels of the Trien-2HCl. These results suggest that fetal brain abnormalities caused by Trien-2HCl may be due in part to induction of copper deficiency, which is almost equiva lent to that in brindled mutant mouse.

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Adhesion between glass/ epoxy composite substrate and copper foil was evaluated by 90 ± peeling test. Effect of fracture behavior and the peel strength on copper foil style was experimentally investigated using copper foils with various surface roughness. As mechanical anchoring effect increases with increased surface roughness, the surface roughness increased the surface roughness of copper foil strongly affected the peeling strength and local load variation during the test. The fracture behavior was characterized by secondary electron image and re ective electron image techniques of scanning electron microscopy (SEM). All of the specimens were found to fracture at the anchor points formed in the resin layer on the surface of the substrate. The experimental results were correlated to a formulation based on the theory of beams on elastic foundation, which is presented for predicting the adhesive strength in the adherend-adhesive system. In order to apply this formulation to a no adhesive system, such as FR-4/ copper foil, an analytical model was proposed. In this model, a mixture phase of the copper with the surface resin in the substrate was regarded as the adhesive. The calculated results were in relatively good agreement with the experimental results. It was con rmed that the analysis model and evaluation method is useful to predict the peel strength due to the mechanical anchoring effect.

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This paper presents the temperature dependence of predicting the flexural strength of a carbon fiber-reinforced sheet molding compound (CF-SMC). First, three-point flexural tests were performed to measure strength and elastic modulus at a variety of temperatures for CF-SMC specimens. Next, simple equations for predicting flexural strength were derived based on the fracture mechanics approach. The predicted flexural strength was in reasonably good agreement with the experiment results. The scatter of flexural strength was ascribed to the variation of location and size of the initial damage. In addition, the effect of temperature on flexural strength and delamination behavior was explained in association with the temperature dependence of the elastic modulus and fracture toughness.