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A series of diterpenes were isolated from the fermentation broth of a fungus, Oidiodendron griseum CL37215. The diterpenes were identified as LL-Z1271 a, LL-Z1271/, CJ-14,445, PR 1388, CJ-14,604 and a new diterpene, CJ-14,515. They inhibited both lipopolysaccharide-induced interleukin-lj8 and tumor necrosis factor-a production in human whole blood with IC50s of the range from 0.049 to 100 [IM. Cytokines are produced by a variety of different cell types and act on nearly every tissue and organ1-1. Among identified cytokines, interleukin-1/3 (IL-1/3) and tumor necrosis factor-a (TNF-a) share many properties of

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