Highlights d 18S non-functional rRNA decay requires sequential uS3 ubiquitination d Hel2 and Rsp5 form a K63-linked polyubiquitin chain on uS3 monoubiquitinated by Mag2 d uS3 ubiquitination induces subunit dissociation of nonfunctional 80S by Slh1 (Rqt2)

Fires set for slash-and-burn agriculture contribute to the current unsustainable accumulation of atmospheric greenhouse gases, and they also deplete the soil of essential nutrients, which compromises agricultural sustainability at local scales. Integrated assessments of greenhouse gas emissions have compared intensive cropping systems in industrialized countries, but such assessments have not been applied to common cropping systems of smallholder farmers in developing countries. We report an integrated assessment of greenhouse gas emissions in slash-and-burn agriculture and an alternative chopand-mulch system in the Amazon Basin. The soil consumed atmospheric methane (CH 4 ) under slash-and-burn treatment and became a net emitter of CH 4 to the atmosphere under the mulch treatment. Mulching also caused about a 50% increase in soil emissions of nitric oxide and nitrous oxide and required greater use of fertilizer and fuel for farm machinery. Despite these significantly higher emissions of greenhouse gases during the cropping phase under the alternative chop-and-mulch system, calculated pyrogenic emissions in the slash-and-burn system were much larger, especially for CH 4 . The global warming potential CO 2 -equivalent emissions calculated for the entire crop cycles were at least five times lower in chop-and-mulch compared with slash-and-burn. The crop yields were similar for the two systems. While economic and logistical considerations remain to be worked out for alternatives to slash-and-burn, these results demonstrate a potential 'win-win' strategy for maintaining soil fertility and reducing net greenhouse gas emissions, thus simultaneously contributing to sustainability at both spatial scales.

The present study indicates that chemotherapy with AZD7762 and cisplatin should be explored as a treatment modality for women with ovarian clear cell carcinoma.

The slash-and-burn practice of land preparation that farmers use traditionally in forest-based fallow systems in the humid tropics causes land degradation and human health hazards. As an alternative to slash-and-burn, a mechanized, fire-free method of land preparation was evaluated on smallholdings in the eastern Amazon region. The use of machinery for harvesting fallow vegetation and chopping it for mulch eliminates the need for hard labor and fire for land clearing and increases labor productivity. Four different tractor-propelled choppers with power demand of 50 kW to 122 kW were tested. Their chopping capacity varied between 4.5 Mg and 20 Mg of fresh biomass per hour. The mechanized chop-and-mulch technology can be used in fallow vegetation that is up to 12 years old, which in the study region corresponded to 20 Mg to 150 Mg fresh biomass per hectare. Two additional choppers-a stationary silage chopper and a high-powered crawler tractor with a chopping device-were also tested but both were not suitable for smallholder fallow systems. In the context of the mulch technology, new low-input crop varieties were screened and their response to fertilizer was studied. The mulch technology facilitates extended cropping, to plant crops off-season, and modify crop rotation. Degraded fallow vegetation can be improved by enrichment planting using fast-growing leguminous tree species. Financial analysis of different scenarios revealed that farm income and labor productivity from chop-and-mulch systems can be up to two times greater than from the traditional slash-and-burn system.