Indomethacin may injure the small intestine through a TLR4/MyD88-dependent pathway.

By preventing tumor ingrowth and migration, covered SEMSs with an anti-migration system had a longer duration of patency than uncovered SEMSs, which recommends their use in the palliative treatment of patients with biliary obstruction due to pancreatic carcinomas.

Overlaps among GERD, FD and IBS were common and worsened HR-QOL in Japanese general population.

No abstract

Approximately 6.6% of Japanese have GERD and most persons with GERD described heartburn or acid regurgitation as bothersome.