Background: Management of abortion is an important issue in gynecology. Several millions of spontaneous abortions occur yearly and more than a million induced abortions are performed in the USA. Objectives: The aim of this study was to compare the effect of misoprostol alone and misoprostol with letrozole in the induction of abortion in the first trimester of pregnancy in the Qazvin city of Iran. Patients and Methods: Seventy female candidates for legal abortion within the first trimester of pregnancy were divided to two groups: misoprostol alone and misoprostol with letrozole. The complete abortion, time to open the internal os of the cervix, time to complete the abortion, and drug-induced side effects of misoprostol and letrozole were recorded and analyzed. Results: The complete abortion rate was 69.7% in the misoprostol and letrozole group and 30.3% in the misoprostol group. Incomplete abortion was 32.4% in the misoprostol and letrozole group, and 67.6% in the misoprostol group (P = 0.004). Bleeding, cervix os opening time, and time to complete abortion from induction of drugs were similar in both groups (P > 0.05). There were no medical complications in both groups. Conclusions: Misoprostol plus letrozole was more effective for inducing abortion in the first trimester of pregnancy compared to misoprostol alone.

Introduction: In the present study, the effects of prenatal stress on spatial learning and memory deficit and its relationship with hippocampal insulin resistance was examined in male and female offspring. Method: Female NMRI mice were mate with males overnight and the zero day of pregnancy was detected (Gestational day zero-GD0). The pregnant mice were then randomly divided into stress and control groups. The stress group received stress from the GD0 to GD10. On post natal day 30 (PND30) the offspring were divided into for subgroups namely: male-control, female-control, male-stress, and female-stress. Barnes maze (BM) method was used for spatial learning evaluation. Plasma cortisol and insulin levels were measured at the beginning of the experiments. At the end of the experiments, the animals’ brains were removed and their hippocampus was extracted. The hippocampus was homogenized and its insulin and insulin receptor contents were evaluated. Results: The stressed animals needed more time for reaching to target hole. In addition, they spend more distance for finding the target hole, which was more pronounced in the male offspring. Both plasma and hippocampal insulin content were reduced in stressed groups. Moreover, the hippocampal insulin receptors protein was reduced in the stressed animals. There was a positive relationship between plasma and hippocampal content and memory deficit in the stressed groups. Conclusion: These results indicated that prenatal stress can induce spatial learning and memory deficit in offspring which is associated with plasma and hippocampal insulin and receptor content reduction (hippocampal insulin resistance) in these animals.

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