Smoking habits are common in schizophrenic patients. Nicotine can suppress negative symptoms and cognitive impairments. The aim of this study was to determine the efficacy of bupropion on cognitive function in schizophrenic patients. This study is a double blind randomized controlled trial in a large referral psychiatric university hospital in Iran. Ninety smoker schizophrenic patients were randomly allocated (based on DSM -IV TR criteria) in two groups (46 patients for case group and 44 patients in control group). They get risperidone up to 6 mg/d and bupropion up to 400 mg/d .clinical assessment (Positive and Negative Syndrome Scale (PANSS), Brief psychiatric rating scale (BPRS) were taken in beginning of study, 14 th and 28 th days of study. Cognitive assessment (Stroop, Digit Span, and Wechsler, Wisconsin) were taken in begging of study, the days 2 nd , 7 th , 14 th , 28 th . All data were analyzed by SPSS Ver. 17 with analytic and descriptive tests. Mean age of patients was 37.66±1.01. Mean duration of disorder was 11.63±.98 years. The scores were significantly lower at the day 28 th compared to the beginning of the study in both groups in Wechsler, Stroop color word , Stroop word , Stroop color , BPRS, PANSS p value ≤0.05 .The difference between the two treatments was not significant as indicated by the effect of group, the between-subjects factor p value ≥0.05. In this study, the side effects were examined and there was no significant difference between the two groups p value ≥0.05. Augmentation of bupropion to routine treatment improves cognitive symptoms of schizophrenia in abstinence of tobacco.

Objectives: In the present study, Cloninger's dimensions of temperament and character have been investigated in patients with bipolar mood disorder-I (BMD-I), and obtained results were compared to those of healthy control participants from the general population. Method:This cross sectional study investigates 96 patients with BMD-I, selected based on DSM-IV-TR criteria, who are admitted into a psychiatry hospital due to an acute episode of mania, depression or mixed episode in year 2011 in Iran.After stabilization of acute phase, patients completed the 125-item Persian version of Temperament and Character Inventory (TCI). Seven dimensions of temperament and character were compared between the designated bipolar group and 1212 healthy individuals via independent samples t-test. Moreover, the correlation between age,duration of disorder, and mood variables (depression and mania scores) with temperament and character inventory scores were assessed by Pearson's correlation coefficient. Results: Bipolar patients showed significantly higher harm avoidance (P=.001) and lower reward dependency (P=.001), persistence (P=.044), cooperativeness (P=.001), self-directedness (P=.001) and self-transcendence (P=.004) in comparison with healthy individuals. In females, Reward Dependency (P=0.001), Self-Directedness (P=0.001) and Cooperativeness (P=0.001) scores were lower. Furthermore, TCI scores had no significant correlation with scores related to depression and mania, duration of the disorder and marital status. Conclusion: Personality profile of patients with BMD-I differ from those of healthy individuals. Lower scores on Self-Directedness and Cooperativeness in bipolar patients seem to be related with more immature personality traits.