In this research, the Cu-MOF (metal-organic framework, HKUST-1) was synthesized via co-precipitation method and it was into the carbon paste electrode and has been investigated in the measurement of codeine. The electrochemical performance of the modified electrode was evaluated by cyclic voltammetry and differential pulse voltammetry. The effective parameters in the sensitivity of the method were optimized. Quantitative measurements and determination of codeine at the surface of the modified electrode were performed by using differential pulse voltammetry. Finally, the ability of the developed method to measure codeine in real plasma samples was investigated. Under the optimal conditions, the linear range was obtained from 2 to 100 μM with a limit of detection of 0.66 μM. The high efficiency of the developed electrode in plasma samples was proved by using high and acceptable accuracy and satisfactory relative recovery percentage. The results in which the recoveries values with RSD% for three repeated measurements were in the range of 97–109 (%RSD = 3.75 to 4).

In the world of medicine, the discovery of acyclovir, an antiviral medication often used to treat herpes infections, is very important. Accurate and sensitive detection are essential for patient safety since acyclovir is recognized for its possible adverse effects and toxicity at high dosages. A Cu metal-organic framework (MOF) doping with Fe3O4/SiO2 was prepared by direct Co-precipitation method. This binary Fe3O4-SiO2/Cu-MOF was analysis by scanning electron microscopy and X-ray diffraction spectroscopy, and this MOF was used to modify the glassy carbon electrode (GCE) surface. Modified GCE was used for the electrochemical monitoring of Acyclovir in the plasma samples. Acyclovir's electro-oxidation behavior was assessed using cyclic and differential pulse voltammetric techniques. A redox mechanism was postulated based on the effect of the potential scanning rate and solution pH on the voltammetric response of Acyclovir oxidation. A 0.03 μM limit of detection was acquired for Acyclovir analysis with a linear response in the range of 1-60 µM. Finally, acyclovir quantification in the blood serum samples was successfully performed.