Introduction and importance Synovial cell sarcoma (SS) is an extremely rare mesenchymal malignancy, representing nearly 10% of all soft-tissue sarcomas. These high-grade soft tissue sarcomas commonly arise in the para-articular regions of lower extremities. However, 15% of Synovial sarcomas has been described at Unusual locations, including head, neck, and trunk. Herein, we describe the twelfth case of primary synovial cell sarcoma of thyroid with a literature review. Case presentation A 43-year-old woman presented with complaint of a progressive neck mass for the last five-months. She developed with dysphagia and dyspnea nearly 2 months prior, without signs of hoarseness, and weight loss. Ultrasonography in which revealed a heterogeneous, hypervascularized thyroid mass. After total thyroidectomy immunohistochemistry was in favor of primary synovial cell sarcoma of thyroid. The diagnosis was confirmed via Molecular genetic analysis of the SYT-SSX fusion gene transcript using the RT- polymerase chain reaction method. Clinical Discussion: Primary thyroid SVS is an extremely rare malignancy with poor biological behavior. SVS has been known for its tendency to local and distal re-occurrence after a few years of treatment. SS can be classified into two subtypes of monophasic or biphasic based on the presence of mesenchymal and/or epithelial components. Accordingly, the most accurate diagnostic tool for SS is considered to be molecular genetic analysis for SYT/SSX fusion transcript. Conclusion Herein, we reported an extremely rare case of SVS of thyroid gland. These high-grade soft tissue sarcomas mainly present with an asymptomatic rapid growing neck mass. Unspecific clinical presentations and extreme rarity of this disorder, make the diagnosis of thyroid SVS very challenging. Due to paucity of data, there is not enough evidence to establish a reliable mortality rate. However, the prognosis of thyroid SVS seems unfavorable.

Background Adenomas of colon and rectal are frequent colonoscopically found benign lesions. The aim of this study is to evaluate the incidence of polyps among patients referred for colonoscopy and associated histopathological findings. Methods In this retrospective study, patients referred for colonoscopy at Shahid Madani Hospital from were enrolled. The records of the patients were evaluated for demographic data, polyp status along with size and location and type and histopathological findings of the polyps. The data obtained were statistically analyzed using SPSSv22. Results Among 1600 patients who underwent colonoscopy, 260 were positive with polyps. The main symptom among these patients was lower gastrointestinal bleeding 44.2%. The average size of the polyps was 5.68 ± 2.66 and the incidence was significantly greatest among the age group of 51–65 years, p < 0.01. The commonest sites polyps were sigmoid and descending colon, 28.6% and 23.2%, respectively. Adenomatous polyps were the most frequent type, 58.3%. The morphology and pathology of the polyps were significantly associated with each other, p < 0.01. Conclusion Our study evaluates the retrospective data for polyp findings among colonoscopy patients. Early diagnosis of polyps can provide better therapeutic outcomes.

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Surgical Science is one of the branches of medical science that deals with surgical and medicinal interventions, which can cure surgical wounds, cuts, burns and so on. The accelerated recovery process has always been a concern for surgeons and physicians. Standard local antibiotic drugs such as silver nitrate, mafenide acetate, sulfadiazine silver and AgNO3 are also used to treat wounds which are associated with some complications. Considering the fact that no effective herbal remedy has been introduced for wound healing, the purpose of this review is to investigate and identify indigenous Iranian herbs used for wound healing after surgery, especially burn wounds. In this systematic review paper, published articles in the period 1952 to 2017 with keywords of surgery, wound healing, burns, herbs, etc. from databases such as SID, MEDLIB, ProQuest, Magiran, Europe PubMed Central and Google Scholar. Abstract and title of all articles were studied and non-relevant articles were deleted and remaining articles were used for review. Based on the results of the study, Malva sylvestris, Camellia sinensis, Aloe vera, Cydonia oblonga, Scrophularia striata, Centella asiatica, Arnebia euchroma, Calendula officinalis and Hypericum perforatum are the most important herbal remedies for burn restoration. The following is an explanation of the most important herbal remedies for native burn wounds in Iran.

Introduction: Hepatocellular carcinoma (HCC) is the most common that has increased in the recent years around the world. Primary liver cancer or HCC is considered as the 5th and 7th most frequent cancer in males and females, respectively; whereas it is the second leading cause of cancer-related death around the world. Unfortunately, HCC is frequently diagnosed at an advanced phase; while the majority of patients are not having qualification for the remedial therapies in this stage. Furthermore, current systemic chemotherapy demonstrates low efficiency and minimum survival profits. At present, liver cancer therapy is multidisciplinary, and multiple choice treatment are considered mostly on an individualized basis based on the complex interaction of tumor stage and the degree of liver disease, and the patient’s general condition health. Methods: Here we reviewed the new insight into nonsurgical and surgical treatment of liver cancer in five English databases, including Scopus, PubMed, Web of Science, EMBASE, and Google Scholar up to December 2019. Results: The results demonstrated in addition to current therapies such as chemotherapy and surgical resection, new approaches including immunotherapy (with human monoclonal antibodies), virus therapy (with oncolytic viruses such as herpes simplex virus, adenovirus, parvovirus, poxvirus, paramyxovirus, reovirus), gene therapy by novel experimental techniques such as gene directed enzyme/prodrug therapy (P53 gene, microRNA and small-interfering RNA), new ablation therapies radiofrequency ablation, highintensity focused ultrasound, helium cryoablation therapy), as well as adjuvant therapy which widely used method after HCC surgical resection is adjuvant therapy. In recent years, biomaterials approach such ass nanoparticles, liposomes, microspheres, and nanofibers nanoparticles are also considered as the reliable and novel patents to treat and study of liver cancers. Conclusion: Multidisciplinary, and multiple choice treatment and therapy suggestions are available for this liver cancer, whereas there are differences in the management recommendations for liver cancers across specialties and geographic regions. Current findings showed that treatment strategies have combined with the advance of new treatment modalities. Moreover, the use of new approaches with higher efficacy such as combination therapy, the use of biomaterials, ablation therapy, etc are can be considered as the preferred treatments for patients.