Introduction:Crimean-Congo Hemorrhagic fever (CCHF) is a viral hemorrhagic fever which transmitted by tick-bites, or through contact with infected animal tissues or secretions during and immediately post-slaughter. It can be responsible for severe outbreaks in humans. Case Presentation: We have explained five patients of a family with (CCHF), which acquired the illness at one time. Every five patients were admitted to our hospital and they treated by ribavirin promptly. Unfortunately, one patient was referred late to the hospital and the treatment started 96 hours after the beginning of the first sign who expired Conclusions: CCHFV can infect human clustering in a family. To our knowledge, this is the first report of this form in Iran.