Specific dermatoses as skin tags, striae distensae and plantar hyperkeratosis, could be considered as a cutaneous stigma of severe obesity. The low permeability of the skin to evaporative water loss is observed in obese subjects compared with normal weight control. Although the physiological mechanisms are still unknown, this finding has not been previously described and we believe that this may constitute a new field in the research on obesity.
Obese adult patients have many dermatoses, such as skin tags, candida infection, cellulite, and intertrigo, but only limited data have been published on obese children and the barrier function of their skin. Sixty-five overweight and obese children (n = 40, BMI 85th-95th percentile; n = 25, BMI > 95th percentile) (aged 8-15; mean age 11.6) and 30 normal-weight controls (aged 7-15; mean age 11.1) underwent a clinical evaluation and calculation of transepidermal water loss (TEWL). Higher weight percentile was associated with a higher incidence of some dermatoses. Skin tags were found in 40% of subjects in the 95th percentile and 2.5% of those in the 85th percentile. Striae distensae were observed in 32% of patients in the 95th percentile and 22.5% of those in the 85th percentile. Plantar hyperkeratosis was observed only in 20% of the 95th percentile subjects and was not observed in the other groups. TEWL values at the forearm site were significantly higher (p < 0.05) in obese children than in the control group, but no significant differences in TEWL values according to BMI level were found between the two groups of obese children. Degree of obesity influences the incidence of some associated dermatoses; skin tags, striae distensae, and plantar hyperkeratosis were more frequent in children in the 95th percentile of BMI. Obesity increases the TEWL rate, suggesting that obese children might become more easily overheated as weight increases, with more profuse sweating because of the thick layers of subcutaneous fat.
References1 Friboes W. Beitrag zur Klinik und Histopathologie der gutartigen Hautepitheliome . S. Karger-Verlag, Berlin, 1912. 2 Kleine-Natrop HE. Simultaneous generalization of benign basalioma of both Spiegler and Brooke types. Arch Klin Exp Dermatol 1959; 209 : 45 -55. 3 Volter C, Baier G, Schwager K et al. Cylindrocarcinoma in a patient with Brooke-Spiegler syndrome. Laryngorhinootologie 2002; 81 : 243 -246. 4 Durani BK, Kurzen H, Jaeckel A et al. Malignant transformation of multiple dermal cylindromas. Br J Dermatol 2001; 145 : 653 -656. 5 Pizinger K, Michal M. Malignant cylindroma in Brooke-Spiegler syndrome. Dermatology 2000; 201 : 255 -257. 6 McKee PH, Fletcher CD, Stavrino P, Pambakian H. Carcinosarcoma arising in eccrine spiradenoma. Am J Dermatopathol 1990; 12 : 335 -343. 7 Grouls V, Iwaszkiewicz J, Berndt R. Malignes ekkrines Spiradenom. Z Hautkr 1991; 66 : 892-895. 8 Meriggi F, Tagliabo R, Morone G et al. The potential malignancy of eccrine spiradenoma. Ital J Surg Sci 1989; 19 : 265 -268. 9 Biernat W, Peraud A, Wozniak L, Ohgaki H. P53 mutations in sweat gland carcinomas. Int J Cancer 1998; 76 : 317 -320. 10 Mutoh H, Nagata H, Ohno K et al. Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas. Int J Oncol 2001; 18 : 781-786. References 1 Hull PR, D'Arcy C. Isotretinoin use and subsequent depression and suicide: presenting the evidence. Am J Clin Dermatol 2003; 4: 493 -505. 2 Bremner JD. Does isotretinoin cause depression and suicide? Psychopharmacol Bull 2003; 37: 64 -78. 3 O'Connell KA, Wilkin JK, Pitts M. Isotretinoin (Accutane) and serious psychiatric adverse events. J Am Acad Dermatol 2003; 48: 306 -308. 4 Chu A, Cunliffe WJ. The inter-relationship between isotretinoin/ acne and depression. J Eur Acad Dermatol Venereol 2003; 17: 619. 5 Gupta MA. Incidence of psychiatric disorders in dermatological patients. J Eur Acad Dermatol Venereol 2003; 17: 624 -626. 6 Jacobs DG, Deutsch N, Brewer M. Suicide, depression, and isotretinoin: is there a causal link? J Am Acad Dermatol 2001; 45: S168 -S175. 7 Wysowski DK, Pitts M, Beitz J. An analysis of reports of depression and suicide in patients treated with isotretinoin. J Am Acad Dermatol 2001; 45: 515 -519. 8 Jick SS, Kremers HM, Vasilakis-Scaramozza C. Isotretinoin use and risk of depression, psychotic symptoms, suicide, and attempted suicide.
Spitz nevus is an uncommon, benign melanocytic neoplasm that shares many clinical and histological features with melanoma. It presents clinical ambiguity that makes the diagnosis and management of the patient difficult. We present our experience in the management of Spitz nevus by rigorous dermoscopic long-term follow-up of 8 Spitz nevi in patients younger than 12 years. Dermoscopic images, acquired every 6 months, show evolution and modifications of these lesions. The aim of this paper is to better understand the long-term modifications of nevi with starburst pattern to avoid surgical excision of these lesions in the pediatric age group.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.