Existing reinforced concrete (RC) bridges that were designed in the decades between 1950 and 1990 exhibit inadequate structural safety with reference to both traffic loads and hazard conditions. Competent authorities are planning extensive inspections to collect data about these structures and to address retrofit interventions. In this context, Remotely Piloted Aircraft Systems (RPASs) represent a prospect to facilitate in-situ inspections, reducing time, cost and risk for the operators. A practice-oriented methodology to perform RPAS-based surveys is described. After that, a workflow to perform an in-situ RPAS inspection oriented to a photogrammetric data extraction is discussed. With the aim to connect the advantages of the RPAS technologies to the seismic risk assessment of bridges, a simplified mechanic-based procedure is described, oriented to map the structural risk in road networks and support prioritization strategies. A six-span RC bridge of the Basilicata road network, representing a typical Italian bridge typology is selected to practically describe the operating steps of the RPAS inspection and of the simplified seismic risk assessment approach.