Regular exercise plays an important preventive and therapeutic role in heart and vascular diseases, and beneficially affects brain function. In blood, the effects of exercise appear to be very complex and could include protection of vascular endothelial cells via neurotrophic factors and decreased oxidative stress. The purpose of this study was to identify the age-related changes in peripheral brain-derived neurotrophic factor (BDNF) and its relationship to oxidative damage and conventional cardiovascular disease (CVD) biomarkers, such as atherogenic index, C-reactive protein (hsCRP) and oxidized LDL (oxLDL), in active and inactive men. Seventeen elderly males (61-80 years) and 17 young males (20-24 years) participated in this study. According to the 6-min Åstrand-Rhyming bike test, the subjects were classified into active and inactive groups. The young and elderly active men had a significantly better lipoprotein profile and antioxidant status, as well as reduced oxidative damage and inflammatory state. The active young and elderly men had significantly higher plasma BDNF levels compared to their inactive peers. BDNF was correlated with VO2max (r=0.765, P<0.001). In addition, we observed a significant inverse correlation of BDNF with atherogenic index (TC/HDL), hsCRP and oxLDL. The findings demonstrate that a high level of cardiorespiratory fitness reflected in VO2max was associated with a higher level of circulating BDNF, which in turn was related to common CVD risk factors and oxidative damage markers in young and elderly men.

Carnosine is a dipeptide formed from the amino acids β-alanine and histidine and found in large amounts in the brain and muscle, especially fast twitch muscle. Carnosine has an antioxidant role and accounts for about 10% of the muscle's ability to buffer the H+ ions produced by high intensity exercise. Due to the interesting role of carnosine, the aim of the study was observe the effects of carnosine intake on pro-antioxidant status in highly trained athletes exposed to intense exercise.Fourteen male athletes from the Polish national kayak and canoe teams participated in placebo-controlled and cross-over study. The athletes were supplemented with 4 g/d carnosine for 14 days. Blood samples were collected before and 30 min, 24 h and 48 h after 2000 m exercise trial. In blood, hydrogen peroxide (H2O2), nitric oxide (NO), markers of RO/NS activity 8-isoprostanes and 3-nitrotyrosine, total (GSHt) and oxidised glutathione (GSSG), antioxidant status (APO) and superoxide dismutase (SOD) were determined. There were not observed statistically significant differences in exercise-induced changes in H2O2 and NO concentrations and SOD activity after carnosine intake. However, carnosine prevented an increase in 8-isoprostanes, 3-nitrotyrosine and GSSG concentrations as well as elevated redox status (GSHt-2GSSG)/GSSG at post-exercise period.Although, oral supplementation with 4 g carnosine did not affect RO/NS generation, it significantly attenuated exercise-induced glutathione loss, reduced oxidation/nitration markers concentration and SOD activity. These results suggest that carnosine could provide antioxidative protection for highly trained athletes.

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The aim of this study was to determine the extent of asymmetry of spinal segment mobility in canoeists. Moreover, the relationship between this parameter and racing speed was analyzed. The study included 18 canoeists with a mean age of 16.4 years. Mobility of cervical, thoracic and lumbar spine, in sagittal, coronal and transverse planes, was measured with the aid of a tensometric electrogoniometer. The racing speed was based on results achieved during the qualifying competition for the Polish national team. Spinal mobility was measured within two days after the competition. Significant associations were observed between average racing speed and the asymmetry coefficients of the cervical (r=−0.52; p=0.03) and lumbar spinal flexure in the coronal plane (r=0.57; p=0.01). The extent of the asymmetry of the cervical spine flexure in the coronal plane should possibly be reduced, because such asymmetry exerts a negative effect on racing speed. In contrast, canoeist’s training should be oriented towards increasing the asymmetry of the lumbar spine flexure in the coronal plane. However, one should keep in mind that such an approach, although favorable in terms of race performance, could negatively affect the canoeist’s health.

Purpose. The study aims at assessment of body composition and muscle mass distribution in advanced kayakers. Kayak paddlers should be characterized by large body mass with a significant percentage of muscle mass, especially in the trunk region. Basic procedures. The sample consisted of 26 kayakers. The body composition and muscle mass distribution were determined based on bioelectrical impedance analysis. Main findings. The subjects had large muscle mass and average fat mass. The percentage of body fat mass in the kayakers was observed to increase with age, whereas the muscle mass percentage decreased, with the exception of the limbs. Conclusions. BIA of body composition and distribution of muscle mass should be a standard diagnostic method to collect data on proper adaptation of kayakers to their training programs.