Neonatal hypoglycemia is common and may often be undetected in new born infants. 1 It has been associated with permanent brain injury, seizures, poor vision, and poor neurodevelopment in affected babies. 2 However, the definition of neonatal hypoglycemia and the best course of treatment remain a contentious subject. 1,3,4 Continuous glucose monitoring (CGM) devices, with their 1-to 5-minute measurement interval, have recently been used to identify hypoglycemia in a more effective, less invasive manner than blood glucose (BG) measurements alone. 1,5-7 CGM devices typically consist of a small pagerlike monitoring device that receives a signal from a sensor inserted into the subcutaneous layer, just beneath the skin. Calibration algorithms convert the signal into a meaningful glucose concentration by comparing it to known calibration 524857D STXXX10.