Abstract Helianthemum nummularium is a European shrub growing at high altitude where it copes with a high level of stress. It was found to be overexpressed in ungulates diets compared to more abundant surrounding plants. These elements combined with the fact that H. nummularium from the Alps has never been investigated prompted us to study the phytochemical composition of its aerial parts. The analysis of the polar extract allowed for the isolation of eight compounds: p-hydroxybenzoic acid, tiliroside, kaempferol, astragalin, quercetin, plantainoside B, quercetin-3-O-glucoside, and quercetin-3-O-glucuronide. We investigated the effect of the polar extract and isolated compounds on nuclear factor erythroid 2-related factor 2 transcription factor, which regulates the expression of a wide variety of cytoprotective genes. We found that the ethanolic extract activates the expression of nuclear factor erythroid 2-related factor 2 in a dose-dependent manner, whereas the pure compounds were much less active. The activation of the nuclear factor erythroid 2-related factor 2 pathway by the plant extract could pave the way for studies to promote healthy aging through protection of cells against oxidative stress. Moreover, the isolated compounds could be investigated alone or in combination in the perspective of making the link between the ungulateʼs preference for this plant and possible use of it for self-medication.

Pour Mathieu Agostini, membre du comité des Assises pour l’Écosocialisme et du Parti de Gauche, les problèmes écologiques actuels sont l'occasion de poser à nouveau frais la question de la capacité du mode de production capitaliste, non seulement à résoudre ces questions mais plus encore, à se survivre à lui-même. Tournant le dos au réformisme, l'auteur prône un programme politique de rupture avec le libéralisme, fondé sur la notion de mode de production écosocialiste. Restaurer la propriété collective des communs, et la planification écologique, mettre en place un service public de l'énergie, (re)centraliser la recherche et le développement, abolir l'obsolescence programmée et développer des filières de dépollution et de recyclage... Le programme est riche et plein d'espoirs mais ne laisse-t-il pas une impression de déjà vu ?

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