Pt(ii) and Pd(ii) complexes with unprecedented photophysical properties were developed. Encapsulation in nanoparticles boosted their performance while rendering them as self-referenced oxygen sensors.

The small arginine-rich protein protamine condenses complete genomic DNA into the sperm head. Here, we applied its high RNA binding capacity for spontaneous electrostatic assembly of therapeutic nanoparticles decorated with tumour-cell-specific antibodies for efficiently targeting siRNA. Fluorescence microscopy and DLS measurements of these nanocarriers revealed the formation of a vesicular architecture that requires presence of antibody-protamine, defined excess of free SMCC-protamine, and anionic siRNA to form. Only these complex nanoparticles were efficient in the treatment of non-small-cell lung cancer (NSCLC) xenograft models, when the oncogene KRAS was targeted via EGFR-mediated delivery. To show general applicability, we used the modular platform for IGF1R-positive Ewing sarcomas. Anti-IGR1R-antibodies were integrated into an antibody-protamine nanoparticle with an siRNA specifically against the oncogenic translocation product EWS/FLI1. Using these nanoparticles, EWS/FLI1 knockdown blocked in vitro and in vivo growth of Ewing sarcoma cells. We conclude that these antibody-protamine-siRNA nanocarriers provide a novel platform technology to specifically target different cell types and yet undruggable targets in cancer therapy by RNAi.

The synthesis, structure, magnetic, and photophysical properties of two dinuclear, luminescent, mixedligand [Cr III 2 L(O 2 CR)] 3 + complexes (R = CH 3 (1), Ph (2)) of a 24membered binucleating hexa-aza-dithiophenolate macrocycle (L) 2À are presented. X-ray crystallographic analysis reveals an edge-sharing bioctahedral N 3 Cr(μ-SR) 2 (μ 1,3 -O 2 CR)CrN 3 core structure with μ 1,3 -bridging carboxylate groups. A ferromagnetic superexchange interaction between the electron spins of the Cr 3 + ions leads to a high-spin (S = 3) ground state. The coupling constants (J = + 24.2(1) cm À 1 (1), + 34.8(4) cm À 1 (2), H = À 2JS 1 S 2 ) are significantly larger than in related bis-μalkoxido-μ-carboxylato structures. DFT calculations performed on both complexes reproduce both the sign and strength of the exchange interactions found experimentally. Frozen methanol-dichloromethane 1 : 1 solutions of 1 and 2 luminesce at 750 nm when excited into the 4 LMCT state on the 4 A 2 ! 2 T 1 (ν 2 ) bands (λ exc = 405 nm). The absolute quantum yields (Φ L ) for 1 and 2 were found to be strongly temperature dependent. At 77 K in frozen MeOH/CH 2 Cl 2 glasses, Φ L = 0.44 � 0.02 (for 1), Φ L = 0.45 � 0.02 (for 2).

The front cover artwork is provided by the group of Jun.‐Prof. Dr. Jens Voskuhl [Universität Duisburg‐Essen (UDE), Germany]. The cover image shows deep‐sea frog fishes known to attract their prey by using a light emitting organ. Here we adapted the illustration by adding the corresponding chalcogen as a lantern, shining in the corresponding emission colour as described in the contribution. Read the full text of the Article at 10.1002/cptc.202000002.