In April 2020, at the onset of COVID-19 in the U.S., we implemented a weekly survey of underrepresented undergraduate students participating in a biomedical research training program. The 10-week survey collected qualitative and quantitative data on mental health, physical health, and financial health. Responses indicated high stress during the pandemic, particularly during the survey’s final weeks which occurred during a period of social unrest. Physical health declined throughout the survey, stabilizing in its final weeks. Financial health declined initially and stayed low throughout. Students from certain demographic groups, such as first generation college students and those with dependents were disproportionately impacted. Qualitative responses highlighted the intersectionality of the three constructs and illustrated the impacts of these events.