Introduction: Although optimization of atrioventricular and interventricular delays has been demonstrated to improve hemodynamics in patients with cardiac resynchronization therapy (CRT), segments (Tmsv 16-SD), six basal and six mid segments (Tmsv 12-SD), and the six basal segments (Tmsv 6-SD) were assessed as a asynchrony indexes. LV end-diastolic and endsystolic volumes (EDV, ESV), stroke volume (SV), ejection fraction (EF), myocardial performance index (MPI), ejection time (ET), and filling time (FT), corrected by R-R interval, were also evaluated. After IEGM optimization, as compared with baseline Tmsv 12-SD and Tmsv 16-SD decreased (P = 0.01, P< 0.001, respectively), EF and SV improved (P < 0.001, P = 0.01 respectively), FT/RR and ET/RR increased (P = 0.02 for both), and MPI improved (P < 0.001). Tmsv 6-SD, EDV and ESV did not change.Conclusion: A simple IEGM-based method of CRT optimization decreased LV dyssynchrony and improved systolic function. (PACE 2008; 31:56-63) cardiac resynchronization therapy optimization, real-time 3D echocardiography, atrioventricular, interventricular delay Introduction Cardiac resynchronization therapy (CRT) is effective in the management of moderate-to-severe heart failure (HF) due to systolic dysfunction and associated cardiac asynchrony. A wide variety of studies have shown that CRT improves cardiac function, quality of life, and exercise capacity; alleviates symptoms; shortens hospitalizations; and lowers mortality. 1-3 These advantages conferred by CRT are currently thought to be mainly related

Abstract.A color decorrelation strategy to improve the human or automatic readability of degraded documents is presented. The particular degradation that is considered here is bleed-through, that is, a pattern that interferes with the text to be read due to seeping of ink from the reverse side of the document. A simplified linear model for this degradation is introduced to permit the application of very fast decorrelation techniques to the RGB components of the color data images, and to compare this strategy to the independent component analysis approach. Some examples from an extensive experimentation with real ancient documents are described, and the possibility to further improve the restoration performance by using hyperspectral/multispectral data is envisaged.

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