Superior mesenteric artery (SMA) syndrome often presents with small bowel obstruction due to acute angulation of the SMA, thereby compressing the duodenum. This syndrome is a rare, sporadic disease, which is often caused by rapid weight loss. However, there may be a genetic predisposition to SMA syndrome, due to a congenitally shortened ligament of Treitz or a more distal origination of the SMA on the abdominal aorta. In this study, we present a patient who was diagnosed with SMA syndrome despite not exhibiting the classic weight-loss clinical picture. Interestingly, the patient reported a family history of SMA syndrome in her mother who had experienced a similar presentation.